Yalcin Serenat Eris, Ocal Irfan, Yalcin Yakup, Selim Halime Sen, Caltekin Melike Demir, Aydogmus Huseyin, Kelekci Sefa
Department of Perinatology, Süleyman Demirel University School of Medicine, Isparta, Turkey.
Department of Pathology, İzmir Katip Çelebi Univesity School of Medicine, Atatürk Training and Research Hospital, İzmir, Turkey.
Eurasian J Med. 2017 Jun;49(2):107-112. doi: 10.5152/eurasianjmed.2017.17070.
The reasons why endometriosis is more aggressive and invasive in some patients are unknown. Despite the importance of population-based clinically defined risk factors in the prediction of recurrence, biochemical markers obtained from the patient are more valuable for prediction on an individual basis. Therefore, the discovery of significant potential biomarkers could be useful to clinicians for shedding light on the pathogenesis of endometriosis and in the monitoring recurrence.
This study included 50 patients who underwent surgery for ovarian cysts that were diagnosed as endometrioma. The age of the patients, stage of the endometriosis, diameter and localization of endometriomas, type of surgery, and pre- and postoperative cancer antigen 125 (CA125) levels were compared between patients with and without recurrence. The archived pathology slides were stained with Ki-67 and anti-urocortin antibodies for reevaluation. By comparing the pathology parameters of the patients with and without recurrence, the association between these parameters and recurrence was investigated.
The median Ki-67 proliferation index of the patients with recurrence (7.5±6.5) was statistically significant compared with that of the patients without recurrence (1±4) (p=0.003). The urocortin epithelial staining intensity and percentage were not found to be statistically significant in comparison. A statistically significant difference was determined between postoperative CA125 median levels of patients without recurrence (10±17.6) and those of patients with recurrence (29.9±18.1) (p=0.003).
The Ki-67 proliferation index may be useful for predicting prognosis and recurrence risk.
子宫内膜异位症在某些患者中更具侵袭性和转移性的原因尚不清楚。尽管基于人群的临床定义风险因素在预测复发方面很重要，但从患者身上获得的生化标志物对于个体预测更有价值。因此，发现重要的潜在生物标志物可能有助于临床医生了解子宫内膜异位症的发病机制并监测复发情况。
本研究纳入了50例接受手术治疗卵巢囊肿（诊断为卵巢子宫内膜异位囊肿）的患者。比较了复发患者和未复发患者的年龄、子宫内膜异位症分期、卵巢子宫内膜异位囊肿的直径和位置、手术类型以及术前和术后癌抗原125（CA125）水平。对存档的病理切片进行Ki-67和抗促肾上腺皮质激素释放肽抗体染色以进行重新评估。通过比较复发患者和未复发患者的病理参数，研究这些参数与复发之间的关联。
复发患者的Ki-67增殖指数中位数（7.5±6.5）与未复发患者（1±4）相比有统计学意义（p=0.003）。相比之下，促肾上腺皮质激素释放肽上皮染色强度和百分比没有统计学意义。未复发患者术后CA125中位数水平（10±17.6）与复发患者（29.9±18.1）之间存在统计学显著差异（p=0.003）。
Ki-67增殖指数可能有助于预测预后和复发风险。
