Membrane Biophysics Group, Niels Bohr Institute, University of Copenhagen, Denmark.
Membrane Biophysics Group, Niels Bohr Institute, University of Copenhagen, Denmark.
Biochim Biophys Acta Biomembr. 2018 Oct;1860(10):2145-2153. doi: 10.1016/j.bbamem.2018.04.003. Epub 2018 Apr 19.
In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference necessary to induce a phase transition in the nerve membrane. It is a function of temperature and pressure, and it is sensitively dependent on the presence of anesthetics which lower melting transitions. We investigate the free energy difference of solid and liquid membrane phases under the influence of anesthetics. We calculate stimulus-response curves of electromechanical pulses and compare them to measured stimulus-response profiles in lobster and earthworm axons. We also compare them to stimulus-response experiments on human median nerve and frog sciatic nerve published in the literature.
在神经刺激的机电理论中，神经冲动由液体环境中固体膜的移动区域组成。因此，刺激脉冲所需的自由能与诱导神经膜相变所需的自由能差直接相关。它是温度和压力的函数，并且对降低相变温度的麻醉剂的存在非常敏感。我们研究了麻醉剂对固体和液体膜相的自由能差的影响。我们计算了机电脉冲的刺激-反应曲线，并将其与龙虾和蚯蚓轴突的测量刺激-反应曲线进行了比较。我们还将其与文献中发表的人类正中神经和蛙坐骨神经的刺激-反应实验进行了比较。
