Department of Orthopedics and Trauma Surgery, University of Cologne, Germany.
Department of Neurosurgery, University of Witten/Herdecke, Cologne Merheim Medical Center (CMMC), Cologne, Germany.
Exp Neurol. 2018 Aug;306:10-21. doi: 10.1016/j.expneurol.2018.04.011. Epub 2018 Apr 19.
Myelotomy is a surgical procedure allowing removal of extravasated blood and necrotic tissue that is thought to attenuate secondary injury as well as promote recovery in experimental spinal cord injury (SCI) models and humans. Here we examined in rat whether myelotomy at 48 h after low-thoracic compressive SCI provided any benefit over a 12 week period. Compared to animals receiving SCI alone, myelotomy worsened BBB scores (p < 0.05) and also did not improve plantar stepping, ladder climbing, urinary bladder voiding or sensory function (thermal latency) during the 12-week period. Quantitative analyses of tissue sections at 12 weeks showed that myelotomy also did not reduce lesion volume nor alter immunohistochemical markers of axons in spared white matter bridges, microglia, astrocytes or serotinergic fibres. However, myelotomy reduced synaptophysin expression, a marker of synaptic plasticity. We conclude that further studies are required to evaluate myelotomy after SCI. (142 words).
脊髓切开术是一种手术程序，允许去除漏出的血液和坏死组织，据认为这可以减轻继发性损伤，并促进实验性脊髓损伤 (SCI) 模型和人类的恢复。在这里，我们在大鼠中研究了在低胸压缩性 SCI 后 48 小时进行脊髓切开术是否在 12 周内提供任何益处。与单独接受 SCI 的动物相比，脊髓切开术使 BBB 评分恶化 (p < 0.05)，并且在 12 周期间也没有改善足底步态、爬梯、膀胱排空或感觉功能 (热潜伏期)。12 周时组织切片的定量分析表明，脊髓切开术也没有减少病变体积，也没有改变保留白质桥内轴突的免疫组织化学标志物、小胶质细胞、星形胶质细胞或血清素能纤维。然而，脊髓切开术降低了突触小体蛋白的表达，这是突触可塑性的标志物。我们得出结论，需要进一步研究 SCI 后的脊髓切开术。(142 个单词)。
