双氯苯氧酮（DuCLOX-2/5 抑制剂）对 N-甲基-N-亚硝脲诱导的白化大鼠乳腺肿瘤的影响。
Effects of phenidone (DuCLOX-2/5 inhibitor) against N-methyl-N-nitrosourea induced mammary gland carcinoma in albino rats.
机构信息
Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, Uttar Pradesh, India.
Department of Pharmaceutical Sciences, King Faisal University, Al-Ahsa, KSA, Saudi Arabia.
出版信息
Toxicol Appl Pharmacol. 2018 Jul 15;351:57-63. doi: 10.1016/j.taap.2018.04.019. Epub 2018 Apr 18.
The present study was designed to evaluate the effects of phenidone (Dual inhibitor of COX-2 and 5-LOX, DuCLOX-2/5 inhibitor) on various aspects of cancer chemoprevention. Treatment with the phenidone was inquested to validate the implications of dual inhibition of arachidonic acid (AA) metabolism against MNU induced mammary gland carcinogenesis. MNU treated rat showed altered hemodynamic profile, distorted cellular architecture, upregulated inflammatory enzyme markers (COX, LOX, Nitric oxide and hydrogen sulfide) and distorted oxidative stress markers (thiobarbituric acid reactive substances, protein carbonyl, superoxide dismutase, catalase and glutathione). Phenidone treatment regulated histological architecture in the experimental animals similar to control. The treatment with phenidone favorably regulated the levels of inflammatory markers, and oxidative stress markers against toxic treatment. Our findings emphasize the potential role of phenidone in suppression of mammary gland carcinoma against the deleterious effects of MNU.
本研究旨在评估苯佐卡因（COX-2 和 5-LOX 的双重抑制剂，DuCLOX-2/5 抑制剂）在癌症化学预防的各个方面的作用。用苯佐卡因进行治疗，以验证双重抑制花生四烯酸（AA）代谢对 MNU 诱导的乳腺肿瘤发生的影响。MNU 处理的大鼠表现出血流动力学谱改变、细胞结构扭曲、炎症酶标志物（COX、LOX、一氧化氮和硫化氢）上调以及氧化应激标志物（硫代巴比妥酸反应物质、蛋白质羰基、超氧化物歧化酶、过氧化氢酶和谷胱甘肽）失调。苯佐卡因治疗使实验动物的组织学结构类似于对照得到调节。苯佐卡因治疗有利于调节炎症标志物和氧化应激标志物的水平，对抗有毒治疗。我们的研究结果强调了苯佐卡因在抑制 MNU 致乳腺肿瘤中的潜在作用。
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