Willis L R, Lynch M
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46240.
Prog Clin Biol Res. 1988;258:205-14.
These studies examined the effects in dogs of dietary Na intake on plasma "ANF-like" immunoreactivity (PAI), and on the renal response to anaritide, a synthetic natriuretic peptide. There were no significant differences between high-Na (120 mEq/day) and low-Na (3 mEq/day) dogs in endogenous PAI, nor was PAI altered by oral or i.v. volume expansion with 0.9% saline. Renal arterial infusion of anaritide did not alter arterial pressure, renal blood flow or the frational excretion of lithium, but increased the fractional excretion of Na to similar degrees in both groups. The peptide increased GFR only in the low-Na group. Extremes of sodium balance do not seem to alter the renal response to anaritide, which apparently does not inhibit sodium reabsorption in the proximal tubule.
这些研究检测了犬类饮食中钠摄入量对血浆“心钠素样”免疫反应性（PAI）的影响，以及对合成利钠肽阿那立肽的肾脏反应的影响。高钠（120毫当量/天）组和低钠（3毫当量/天）组犬的内源性PAI无显著差异，口服或静脉注射0.9%生理盐水进行容量扩张也不会改变PAI。肾动脉注射阿那立肽不会改变动脉血压、肾血流量或锂的排泄分数，但两组中钠的排泄分数均有相似程度的增加。该肽仅在低钠组中增加肾小球滤过率。极端的钠平衡似乎不会改变肾脏对阿那立肽的反应，阿那立肽显然不会抑制近端小管中的钠重吸收。
