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Rapid conjugation in an extremely rapid hydroxylator of debrisoquine: a case report supporting a coregulation of certain phase I and II metabolic reactions.

作者信息

Bertilsson L, Aberg-Wistedt A, Dumont E, Lundström J

机构信息

Department of Clinical Pharmacology, Karolinska Institute, Huddinge Hospital, Sweden.

出版信息

Ther Drug Monit. 1988;10(2):242-4. doi: 10.1097/00007691-198802000-00023.

DOI:10.1097/00007691-198802000-00023
PMID:2968008
Abstract
摘要

相似文献

1
Rapid conjugation in an extremely rapid hydroxylator of debrisoquine: a case report supporting a coregulation of certain phase I and II metabolic reactions.异喹胍超快羟化者中的快速结合：支持某些I相和II相代谢反应共同调节的病例报告
Ther Drug Monit. 1988;10(2):242-4. doi: 10.1097/00007691-198802000-00023.
2
Inhibition of desipramine 2-hydroxylation by quinidine and quinine in rapid and slow debrisoquine hydroxylators.奎尼丁和奎宁对快速和慢速去甲丙咪嗪羟化者中地昔帕明2-羟化的抑制作用。
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3
Interethnic dissociation between debrisoquine and desipramine hydroxylation.异喹胍和地昔帕明羟基化的种族间差异。
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Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype.
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5
Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants.异喹胍的超快速羟基化：一则关于去甲替林及其他三环类抗抑郁药治疗的病例报告及启示
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6
Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes.健康受试者及人肝微粒体中去甲丙咪嗪和异喹胍羟化作用的表型一致性。
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7
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism.丙咪嗪及其代谢产物的稳态浓度与司巴丁/异喹胍多态性的关系。
Eur J Clin Pharmacol. 1986;30(6):679-84. doi: 10.1007/BF00608215.
8
Relationship of N-demethylation of amiflamine and its metabolite to debrisoquine hydroxylation polymorphism.
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9
Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine.司巴丁N-氧化缺陷与异喹胍4-羟化的药物遗传学共变。
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10
Purification of a desmethylimipramine and debrisoquine hydroxylating cytochrome P-450 from human liver.从人肝脏中纯化去甲丙咪嗪和异喹胍羟化细胞色素P-450
Biochem Pharmacol. 1986 Sep 15;35(18):3165-6. doi: 10.1016/0006-2952(86)90403-x.

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Glucuronidation clearance of 8-hydroxyclomipramine in relation to sparteine and mephenytoin phenotype.8-羟基氯米帕明的葡萄糖醛酸化清除率与司巴丁和美芬妥英表型的关系。
Eur J Clin Pharmacol. 1994;47(2):209-10. doi: 10.1007/BF00194975.
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Clomipramine metabolism. Model-based analysis of variability factors from drug monitoring data.氯米帕明代谢。基于模型的药物监测数据变异性因素分析。
Clin Pharmacokinet. 1990 Sep;19(3):241-55. doi: 10.2165/00003088-199019030-00007.
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Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors.
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