Laboratory of Pathology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, 21040-900, Brazil.
Laboratory of Pathology, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, 21040-900, Brazil.
Placenta. 2018 Sep;69:140-145. doi: 10.1016/j.placenta.2018.04.007. Epub 2018 Apr 12.
The placenta plays a major role in the development of blood cells in the mouse and human embryo. Hematopoiesis and vasculogenesis in placenta are two closely interconnected processes. The mouse model has been widely used to study placental hematopoiesis. During mid-gestation, mouse placenta generate blood cells and support the proliferation, maturation and erythroid differentiation of hematopoietic cells within two major vascular niches in the labyrinth. Here, we review the vasculogenesis in chorioallantoic mouse placenta and the current knowledge on hematopoietic activity, niche and origin in mice placenta.
胎盘在小鼠和人类胚胎血细胞的发育中起着重要作用。胎盘中的造血和血管生成是两个密切相关的过程。小鼠模型已被广泛用于研究胎盘造血。在妊娠中期，小鼠胎盘产生血细胞，并在绒毛尿囊胎盘的两个主要血管巢中支持造血细胞的增殖、成熟和红系分化。在这里，我们回顾了鼠胎盘的血管生成以及目前关于小鼠胎盘造血活性、龛和起源的知识。
