一种新型且易于使用的呼吸道合胞病毒诊断分子平台的临床评估

Clinical evaluation of a novel and simple-to-use molecular platform for diagnosis of respiratory syncytial virus.

作者信息

Liikonen Karoliina, Ojalehto Tuomas, Elf Sonja, Mäki Minna, Matero Pirjo, Eboigbodin Kevin E

机构信息

Research and Development, Orion Diagnostica Oy, Espoo, Finland.

出版信息

Anal Biochem. 2018 Jun 15;551:4-6. doi: 10.1016/j.ab.2018.04.017. Epub 2018 Apr 20.

DOI:10.1016/j.ab.2018.04.017

PMID:29680224

Abstract

Rapid molecular diagnostic testing for respiratory infections can improve patient care and minimize unnecessary prescriptions of antibiotics. We present the preliminary clinical evaluation of Orion GenRead RSV, a novel, rapid, and easy-to-use molecular test for the diagnosis of respiratory syncytial virus (RSV) infection. The sensitivity and specificity of Orion GenRead RSV were 99% and 100%, respectively. Orion GenRead RSV detected RSV-positive specimens within 15 min. The performance of Orion GenRead RSV was similar to that of the reference method and this test could rapidly detect RSV within minutes. Orion GenRead RSV is applicable for near-patient testing.

摘要

呼吸道感染的快速分子诊断检测可改善患者护理，并尽量减少不必要的抗生素处方。我们展示了Orion GenRead RSV的初步临床评估，这是一种用于诊断呼吸道合胞病毒（RSV）感染的新型、快速且易于使用的分子检测方法。Orion GenRead RSV的灵敏度和特异性分别为99%和100%。Orion GenRead RSV在15分钟内检测到RSV阳性标本。Orion GenRead RSV的性能与参考方法相似，该检测可在数分钟内快速检测到RSV。Orion GenRead RSV适用于即时检测。