[Signs of developmental dysplasia and function of the genetic apparatus of children and adolescents].

Using scanning cytospectrophotometry and radiometry of beta-particles of 3H-thymidine incorporated into DNA the authors studied chromatin in interphase nuclei of lymphocytes in children and adolescents with Down's syndrome, childhood cerebral paralysis, and undifferentiated oligophrenia, as well as in healthy subjects. The findings obtained are compared with the results of cytogenetic examination of metaphase chromosomes and the number of stigmas of dysembryogenesis. Aberrations of metaphase chromosomes were found in 4.4% of patients with childhood cerebral paralysis and oligophrenia while the pattern of changes in interphase chromatin corresponding to the chromosomal imbalance was detected in 36% of these individuals. In all cases they had from 15 to 30 stigmas of dysembryogenesis.