Braga Letícia Dinis da C, Godoy-Matos Amelio F, Siciliano Priscila de Oliveira, Corrêa José Otávio do Amaral, Carvalho Denise Pires
Metabolism unit, Instituto Estadual de Diabetes e Endocrinologia (IEDE), Rio de Janeiro, RJ, Brazil.
Metabolism unit, Instituto Estadual de Diabetes e Endocrinologia (IEDE), Rio de Janeiro, RJ, Brazil.
Diabetes Metab Syndr. 2018 Sep;12(5):673-675. doi: 10.1016/j.dsx.2018.04.032. Epub 2018 Apr 14.
Dipeptidyl peptidase-4 (DPP4) is an adipokine with greater expression in visceral fat and related with insulin resistance (IR). Polycystic ovary syndrome (PCOS) is also associated with IR. Our study aims to evaluate DPP4 activity in PCOS.
Thirty PCOS patients were compared to 28 healthy women. Body composition by dual X-ray absorptiometry (DXA), plasma activity of DPP4 and biochemical variables were performed. All participants underwent an oral glucose tolerance test for insulin and glucose analysis.
DPP4 activity was similar in both groups (PCOS 5823 ± 926 vs Control 5501.8 ± 975; p = 0.20). PCOS patients were more IR with lower levels of SHBG (32 vs 47, p = 0.02) and Matsuda index (15.6 vs 20.4, p = 0.03) and higher HOMA-IR (2.8 vs 1.7, p < 0.01), in addition to increased levels of testosterone (55 vs 25, p < 0.01). DPP4 was correlated to HbA1c (r = 0.279, p = 0.03), HDL-c (r = -0.28, p = 0.03) and SHBG (r = -0.256, p = 0.05).
Although PCOS was well characterized as IR and hyperandrogenic, DPP4 was not different in this group. However, a relationship between DPP4 and markers of IR were found. More studies are warranted.
二肽基肽酶-4（DPP4）是一种脂肪因子，在内脏脂肪中表达较高，与胰岛素抵抗（IR）相关。多囊卵巢综合征（PCOS）也与IR有关。我们的研究旨在评估PCOS患者的DPP4活性。
将30例PCOS患者与28名健康女性进行比较。采用双能X线吸收法（DXA）测量身体成分，检测DPP4的血浆活性及生化指标。所有参与者均接受口服葡萄糖耐量试验以分析胰岛素和葡萄糖水平。
两组的DPP4活性相似（PCOS组为5823±926，对照组为5501.8±975；p = 0.20）。PCOS患者存在更多IR，其性激素结合球蛋白（SHBG）水平较低（32 vs 47，p = 0.02），松田指数较低（15.6 vs 20.4，p = 0.03），稳态模型评估的胰岛素抵抗指数（HOMA-IR）较高（2.8 vs 1.7，p < 0.01），此外睾酮水平升高（55 vs 25，p < 0.01）。DPP4与糖化血红蛋白（HbA1c）（r = 0.279，p = 0.03）、高密度脂蛋白胆固醇（HDL-c）（r = -0.28，p = 0.03）和SHBG（r = -0.256，p = 0.05）相关。
尽管PCOS具有IR和高雄激素血症的典型特征，但该组患者的DPP4并无差异。然而，发现DPP4与IR标志物之间存在关联。有必要开展更多研究。
