海洛因使用障碍男性在接受美沙酮维持治疗时的食欲素 A。
Orexin A in men with heroin use disorder undergoing methadone maintenance treatment.
机构信息
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.
出版信息
Psychiatry Res. 2018 Jun;264:412-415. doi: 10.1016/j.psychres.2018.04.010. Epub 2018 Apr 7.
Orexins have played a role in reward-seeking and addiction-related behavior. There are few reports in the literature on serum levels of orexins in patients with heroin use disorder (HUD) undergoing methadone maintenance treatment (MMT). The aim of this study was to investigate the serum levels of orexin A in HUD patients undergoing MMT. Fifty male HUD patients undergoing MMT and 25 healthy males were enrolled for this study. Serum orexin A were measured with assay kits. Using analysis of covariance (ANCOVA) with body mass index (BMI) adjustments, the serum levels of orexin A in HUD men undergoing MMT were found to be significantly higher than in healthy controls. In conclusion, our results suggest that MMT might increase orexin A levels in HUD patients.
食欲素在寻求奖励和与成瘾相关的行为中发挥了作用。在接受美沙酮维持治疗（MMT）的海洛因使用障碍（HUD）患者的血清食欲素水平方面，文献中鲜有报道。本研究旨在探讨接受 MMT 的 HUD 患者血清中食欲素 A 的水平。本研究纳入了 50 名接受 MMT 的男性 HUD 患者和 25 名健康男性。使用试剂盒测量血清食欲素 A。采用协方差分析（ANCOVA）调整体重指数（BMI）后，发现接受 MMT 的 HUD 男性的血清食欲素 A 水平明显高于健康对照组。总之，我们的研究结果表明，MMT 可能会增加 HUD 患者的食欲素 A 水平。
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