Arrabal Vela María Auxiliadora, García Gijón Carlota Prado, Pascual Martin María, Benet Giménez Isabel, Áreas Del Águila Vera, Muñoz-Rodríguez José Ramón, Palomo Atance Enrique
Endocrinología Pediátrica, Servicio de Pediatría, Hospital General Universitario Ciudad Real, Ciudad Real, España.
Endocrinología Pediátrica, Servicio de Pediatría, Hospital General Universitario Ciudad Real, Ciudad Real, España.
Endocrinol Diabetes Nutr (Engl Ed). 2018 Jun-Jul;65(6):314-318. doi: 10.1016/j.endinu.2018.02.003. Epub 2018 Apr 19.
Adherence to somatotropin treatment is associated with increased growth velocity and improved adult height. The purpose of this study is to determine the adherence of patients undergoing treatment with an electronic device and its relationship with different variables (age, gender, duration of treatment, diagnosis, height, and growth rate).
Descriptive, longitudinal and retrospective study of children less than 14 years of age undergoing treatment with somatotropin administered with the Easypod® electronic device in the Paediatric Endocrinology Outpatient Clinic of the General University Hospital of Ciudad Real, Spain. Adherence was monitored for 12 months and was defined according to the equation: (days administered at the prescribed dose / prescribed days)×100. The data analysis was performed using SPSS software.
Data were collected from 30 patients, with a predominance of males (57%), a mean age of 6.09 years, with 51% of children less than 5 years old. The most common reasons for the treatment were: small for gestational age (55%) and growth hormone deficiency (38%). The mean duration of treatment was 4.3 years (3.6-5). A mean adherence of 92.3% (87.7-96.9) was observed, and there was a significant correlation with age (Pearson R = -0.384, P=.03), and duration of treatment (Pearson R = -0.537; P=.003).
The adherence in our patients with electronic device is high (92.3%), and is inversely associated with age and duration. The use of electronic devices allows monitoring of therapeutic compliance, which affects the optimisation of treatment.
坚持生长激素治疗与生长速度加快和成人身高改善相关。本研究的目的是确定使用电子设备进行治疗的患者的依从性及其与不同变量（年龄、性别、治疗持续时间、诊断、身高和生长速率）之间的关系。
对西班牙雷阿尔城综合大学医院儿科内分泌门诊使用Easypod®电子设备进行生长激素治疗的14岁以下儿童进行描述性、纵向和回顾性研究。对依从性进行了12个月的监测，并根据以下公式定义：（按规定剂量给药的天数/规定天数）×100。使用SPSS软件进行数据分析。
收集了30例患者的数据，其中男性占多数（57%），平均年龄为6.09岁，51%的儿童年龄小于5岁。治疗的最常见原因是：小于胎龄儿（55%）和生长激素缺乏（38%）。平均治疗持续时间为4.3年（3.6 - 5年）。观察到平均依从性为92.3%（87.7 - 96.9），并且与年龄（Pearson相关系数R = -0.384，P = 0.03）和治疗持续时间（Pearson相关系数R = -0.537；P = 0.003）存在显著相关性。
我们使用电子设备的患者的依从性较高（92.3%），并且与年龄和治疗持续时间呈负相关。电子设备的使用允许监测治疗依从性，这会影响治疗的优化。
