Erikson U, Helmius G, Hemmingsson A, Ruhn G, Olsson A G
Department of Diagnostic Radiology, Akademiska Sjukhuset, University of Uppsala, Sweden.
Acta Radiol. 1988 May-Jun;29(3):303-9.
Femoral arteriography was performed in 62 patients with significant hyperlipidemia. Sixty were asymptomatic and two had intermittent claudication. The patients participated in a study aiming to demonstrate whether serum lipid lowering by drugs could influence the development of femoral artery atheromatous disease. Half of the patients were treated with fenofibrate and nicotinic acid and the other half served as a control group. At the first arteriography atherosclerotic lesions were found in 46 of the 62 patients (74%). Arteriography was repeated up to three times without complication. Visual analysis of angiograms revealed considerable inter-observer variation. An attempt was made to assess the angiograms by a computerized method which, however, still needs improvement and a computer designed for image analysis. Most patients had small or moderate atheromatous deposits in the femoral artery at the initial examination, in most cases showing no change during the study period of 18 months. Regression was found in five patients of the treated group, but in none of the control patients as judged by visual gradation (p less than 0.001).
对62例严重高脂血症患者进行了股动脉造影。其中60例无症状，2例有间歇性跛行。这些患者参与了一项研究，旨在证明药物降低血脂是否会影响股动脉粥样硬化疾病的发展。一半患者接受非诺贝特和烟酸治疗，另一半作为对照组。在首次动脉造影时，62例患者中有46例（74%）发现有动脉粥样硬化病变。动脉造影重复进行多达3次，无并发症发生。血管造影的视觉分析显示观察者之间存在相当大的差异。曾尝试用一种计算机化方法评估血管造影，但该方法仍需改进，并且需要一台用于图像分析的计算机。大多数患者在初次检查时股动脉有小的或中度的动脉粥样硬化沉积物，在18个月的研究期间，大多数病例无变化。根据视觉分级判断，治疗组有5例出现病变消退，而对照组无1例出现病变消退（p<0.001）。
