Olsson A G, Ruhn G, Erikson U
King Gustaf V Research Institute, Stockholm, Sweden.
J Intern Med. 1990 Jun;227(6):381-90. doi: 10.1111/j.1365-2796.1990.tb00176.x.
The development of femoral atheroma after 1 year of treatment with diet and nicotinic acid plus fenofibrate was studied in 45 asymptomatic, hyperlipidaemic, middle-aged male subjects in a non-randomized controlled study. The median serum very low density lipoprotein (VLDL) cholesterol concentration and the low density lipoprotein (LDL) cholesterol concentration were lowered by 67% and 36%, respectively, in the treatment group. The median serum high density lipoprotein (HDL) cholesterol concentration was increased by 23%. Femoral atheroma was estimated by overall atherosclerosis score (OAS). Changes in femoral atherosclerosis were estimated by intrapair comparison of angiograms. Progression was found in 24% and 40% in the treatment and control groups, respectively. Regression occurred in 29% and 0%, respectively. The OAS decrease correlated with reductions in VLDL cholesterol and systolic blood pressure.
在一项非随机对照研究中，对45名无症状、高脂血症的中年男性受试者进行了研究，观察饮食、烟酸加非诺贝特治疗1年后股动脉粥样硬化的发展情况。治疗组的血清极低密度脂蛋白（VLDL）胆固醇浓度中位数和低密度脂蛋白（LDL）胆固醇浓度分别降低了67%和36%。血清高密度脂蛋白（HDL）胆固醇浓度中位数升高了23%。通过总体动脉粥样硬化评分（OAS）评估股动脉粥样硬化。通过血管造影照片的配对内比较来评估股动脉粥样硬化的变化。治疗组和对照组分别有24%和40%出现进展。分别有29%和0%出现消退。OAS降低与VLDL胆固醇和收缩压的降低相关。
