Przylepa K A, Wenger S L
Dept. of Pediatrics, University of Pittsburgh School of Medicine, PA.
Cancer Genet Cytogenet. 1988 Jul 1;33(1):35-8. doi: 10.1016/0165-4608(88)90047-7.
Bone marrow cells from leukemic and nonleukemic patients were examined for chromosome breakage in cultures treated with fluorodeoxyuridine (FUdR) and FUdR plus caffeine. The results indicate that the leukemic cells have more chromosome breakage than the nonleukemic cells when thymidylic synthetase is inhibited by FUdR. Addition of caffeine did not enhance this chromosome breakage. These findings of enhanced breakage by FUdR exposure in vitro, nevertheless, may suggest that leukemic cells in general are more susceptible to breakage than normal cells, thereby predisposing the former to secondary chromosome rearrangements.
对白血病患者和非白血病患者的骨髓细胞进行了检查，观察其在接受氟脱氧尿苷（FUdR）以及FUdR加咖啡因处理的培养物中的染色体断裂情况。结果表明，当胸苷酸合成酶被FUdR抑制时，白血病细胞比非白血病细胞有更多的染色体断裂。添加咖啡因并未增强这种染色体断裂。然而，这些体外FUdR暴露导致断裂增加的发现可能表明，一般来说白血病细胞比正常细胞更容易发生断裂，从而使前者更容易发生继发性染色体重排。
