钴催化手性二炔环三聚反应生成的新型萘基吡啶

Novel naphthylpyridines from cobalt-catalyzed cyclotrimerization of a chiral diyne.

作者信息

Trommer Volkmar, Fischer Fabian, Hapke Marko

机构信息

1Leibniz-Institut für Katalyse an der Universität Rostock (LIKAT), Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.

2Institut für Katalyse (INCA), Johannes Kepler Universität Linz, Altenberger Strasse 69, 4040 Linz, Austria.

出版信息

Monatsh Chem. 2018;149(4):755-763. doi: 10.1007/s00706-017-2083-9. Epub 2017 Nov 28.

DOI:10.1007/s00706-017-2083-9

PMID:29681656

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5906485/

Abstract

ABSTRACT

The concise synthesis of a novel chiral diyne substrate for the assembly of chiral naphthylpyridines was described and different conditions for the cobalt-catalyzed co-cyclotrimerization with nitriles investigated. The products are novel naphthylpyridines possessing configurationally stable biaryl axes.

摘要

描述了一种用于手性萘基吡啶组装的新型手性二炔底物的简洁合成方法，并研究了与腈进行钴催化共环三聚反应的不同条件。产物是具有构型稳定联芳基轴的新型萘基吡啶。