García Estefanny Ruiz, Gutierrez Eliana Alviárez, de Melo Fabiana Cristina Silveira Alves, Novaes Rômulo Dias, Gonçalves Reggiani Vilela
Department of Animal Biology, Federal University of Viçosa, 36570-900 Viçosa, MG, Brazil.
Department of Food Science and Technology, Federal University of Viçosa, 36570-900 Viçosa, MG, Brazil.
Evid Based Complement Alternat Med. 2018 Feb 28;2018:6328970. doi: 10.1155/2018/6328970. eCollection 2018.
The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. It occurs primarily as manifestation of other pathological processes, such as viral hepatitis, cirrhosis, and toxin exposure that affect directly the cellular process. Studies were selected from PubMed and Scopus databases according to the PRISMA statement. The research filters were constructed using three parameters: flavonoids, hepatocellular carcinoma, and animal model. The bias analysis of the 34 selected works was done using the ARRIVE guidelines. The most widely used flavonoid in the studies was epigallocatechin gallate extracted from green tea. In general, the treatment with different flavonoids presented inhibition of tumor growth and antiangiogenic, antimetastatic, antioxidant, and anti-inflammatory activities. The bias analysis evidenced the absence of methodological processes in all studies, such as the age or weight of the animals, the method of flavonoids' extraction, or the experimental designs, analytical methods, and outcome measures. It has been known that flavonoids have a protective effect against HCC. However, the absence or incomplete characterization of the animal models, treatment protocols, and phytochemical and toxicity analyses impaired the internal validity of the individual studies, making it difficult to determine the effectiveness of plant-derived products in the treatment of HCC.
肝细胞癌（HCC）是全球第二大常见癌症死因。它主要作为其他病理过程的表现而出现，如病毒性肝炎、肝硬化以及直接影响细胞过程的毒素暴露。根据PRISMA声明，从PubMed和Scopus数据库中筛选研究。使用三个参数构建研究过滤器：黄酮类化合物、肝细胞癌和动物模型。使用ARRIVE指南对34项所选研究进行偏倚分析。研究中使用最广泛的黄酮类化合物是从绿茶中提取的表没食子儿茶素没食子酸酯。总体而言，用不同黄酮类化合物进行的治疗呈现出抑制肿瘤生长以及抗血管生成、抗转移、抗氧化和抗炎活性。偏倚分析表明所有研究均缺乏方法学过程，如动物的年龄或体重、黄酮类化合物的提取方法，或实验设计、分析方法和结果测量。已知黄酮类化合物对HCC有保护作用。然而，动物模型、治疗方案以及植物化学和毒性分析的缺失或不完整表征损害了各个研究的内部有效性，使得难以确定植物源产品在治疗HCC方面的有效性。
