Brockmeyer N H, Kreuzfelder E, Mertins L, Chalabi N, Kirch W, Scheiermann N, Goos M, Ohnhaus E E
Department of Dermatology, University of Essen, Federal Republic of Germany.
Clin Immunol Immunopathol. 1988 Jul;48(1):50-60. doi: 10.1016/0090-1229(88)90156-0.
The immunomodulatory potency of cimetidine, a histamine H2 receptor antagonist, was investigated in 33 AIDS-related complex (ARC) patients performing detailed immunological and clinical evaluations. Cimetidine was administered orally in daily doses of 1200 mg for a period of 5 months with an interruption of therapy after the first 3 months for an interval of 3 weeks. Significant (P less than 0.05) elevations of immunoglobulins (IgG, IgA), complement C4, B-lymphocytes, and OKT4+ (helper/inducer) cells were found after cimetidine intake. The in vitro lymphocyte proliferative response to plant mitogens was significantly increased, and the in vivo cell-mediated hypersensitivity reaction assessed by intradermal application of seven recall antigens improved significantly. These effects were both reversible with the discontinuation of cimetidine and reproducible with repeated administration of the drug. Clinical data such as performance status, body weight, and fever were influenced favorably (P less than 0.05) by cimetidine. The frequency of diarrhea and the lymph node size were also diminished significantly. The data suggest that cimetidine may at least partially restore immunofunctions in AIDS-related complex.
对33例艾滋病相关综合征（ARC）患者进行了详细的免疫学和临床评估，以研究组胺H2受体拮抗剂西咪替丁的免疫调节效力。西咪替丁口服给药，每日剂量为1200毫克，持续5个月，在前3个月后中断治疗3周。服用西咪替丁后，发现免疫球蛋白（IgG、IgA）、补体C4、B淋巴细胞和OKT4 +（辅助/诱导）细胞显著（P<0.05）升高。对植物有丝分裂原的体外淋巴细胞增殖反应显著增强，通过皮内注射七种回忆抗原评估的体内细胞介导的超敏反应也显著改善。这些作用在停用西咪替丁后均可逆转，且重复给药可再现。西咪替丁对临床数据如体能状态、体重和发热有有利影响（P<0.05）。腹泻频率和淋巴结大小也显著减小。数据表明，西咪替丁可能至少部分恢复艾滋病相关综合征中的免疫功能。
