Miller A, Harel D, Laor A, Lahat N
Department of Neurology, Lady Davis Carmel Hospital, Haifa, Israel.
J Neuroimmunol. 1989 Mar;22(1):69-76. doi: 10.1016/0165-5728(89)90011-8.
As there is evidence of a possible immunoregulatory role for H2-histamine receptor antagonists, we carried out a prospective randomized trial to evaluate the in vivo and in vitro effect of cimetidine, an H2-blocker, in the treatment of herpes zoster infection. Cimetidine treatment shortened the median interval until the first decrease in pain, the median interval until the complete resolution of pain and promoted faster complete healing of skin lesions than symptomatic treatment. The immunological trends observed in vitro support an important role for histamine in the induction of immunosuppression, as measured by the response to the mitogen phytohemagglutinin. This effect of histamine was antagonized by cimetidine.
由于有证据表明H2组胺受体拮抗剂可能具有免疫调节作用，我们进行了一项前瞻性随机试验，以评估H2阻滞剂西咪替丁在治疗带状疱疹感染中的体内和体外效果。与对症治疗相比，西咪替丁治疗缩短了直至疼痛首次减轻的中位间隔时间、直至疼痛完全缓解的中位间隔时间，并促进了皮肤损伤更快地完全愈合。体外观察到的免疫学趋势支持组胺在诱导免疫抑制中起重要作用，这通过对有丝分裂原植物血凝素的反应来衡量。组胺的这种作用被西咪替丁拮抗。
