Iwasaki Tomoaki, Nishibe Toshiya, Ohya Yumiko, Inoue Shigeru, Ogino Hitoshi
Department of Cardiovascular Surgery, Tokyo Medical University, Tokyo, Japan.
Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan.
Ann Vasc Dis. 2018 Mar 25;11(1):96-100. doi: 10.3400/avd.oa.17-00085.
: Recently, reduced serum levels of ω-3 polyunsaturated fatty acids (PUFAs) including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been focused upon as newly recognized risk factors for peripheral artery disease (PAD). The present study investigated the association between disease location and serum levels of ω-3 PUFAs in patients with PAD. : We retrospectively analyzed the data of patients at Tokyo Medical University between August 2011 and November 2015. The subjects included 98 patients who were categorized into two groups: those with (n=72) and without infrainguinal lesions (n=26). : Univariate analysis revealed that low ankle-brachial pressure index (ABI) values, low EPA levels, low DHA levels, low triglyceride levels, and diabetes mellitus were significant risk factors for infrainguinal lesions. Multivariate analysis indicated that low ABI values [p=0.018; odds ratio, 0.043; 95% confidence interval (CI), 0.003-0.579] and low DHA levels (p=0.003; odds ratio, 0.986; 95%CI, 0.977-0.995) were significant independent risk factors for infrainguinal lesions. : Our study demonstrated that reduced serum level of DHA may underlie the presence of infrainguinal lesions in patients with PAD.
最近，血清中包括二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）在内的ω-3多不饱和脂肪酸（PUFAs）水平降低，已成为外周动脉疾病（PAD）新发现的危险因素。本研究调查了PAD患者疾病部位与血清ω-3 PUFAs水平之间的关联。
我们回顾性分析了东京医科大学2011年8月至2015年11月期间患者的数据。研究对象包括98例患者，分为两组：有腹股沟下病变的患者（n = 72）和无腹股沟下病变的患者（n = 26）。
单因素分析显示，低踝臂压力指数（ABI）值、低EPA水平、低DHA水平、低甘油三酯水平和糖尿病是腹股沟下病变的重要危险因素。多因素分析表明，低ABI值[p = 0.018；比值比，0.043；95%置信区间（CI），0.003 - 0.579]和低DHA水平（p = 0.003；比值比，0.986；95%CI，0.977 - 0.995）是腹股沟下病变的重要独立危险因素。
我们的研究表明，血清DHA水平降低可能是PAD患者存在腹股沟下病变的原因。
