CKIP-1在骨质疏松症发生发展及治疗中的作用。

Peng X, Wu X, Zhang J, Zhang G, Li G, Pan X

Department of Orthopaedics and Traumatology, People's Hospital of Bao'an District, Affiliated to Southern Medical University, and Affiliated to Guangdong Medical University, Longjing 2nd Rd, Bao'an District, Shenzhen, China.

Department of Orthopaedics and Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China.

Bone Joint Res. 2018 Apr 12;7(2):173-178. doi: 10.1302/2046-3758.72.BJR-2017-0172.R1. eCollection 2018 Feb.

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. : X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. 2018;7:173-178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1.

骨质疏松症是一种全身性骨骼疾病，其特征为骨量减少和骨微结构破坏，进而导致骨脆性增加和骨折风险升高。酪蛋白激酶2相互作用蛋白1（CKIP-1）是一种在骨形成调节中起重要作用的蛋白质。CKIP-1对骨形成的影响主要通过对骨形态发生蛋白通路的负调控来介导。此外，CKIP-1在骨质疏松症的进展中也具有重要作用。本综述总结了近期关于CKIP-1在骨质疏松症发生发展及治疗中作用的研究。：彭X、吴X、张J、张G、李G、潘X。CKIP-1在骨质疏松症发生发展及治疗中的作用。2018；7：173 - 178。DOI：10.1302/2046 - 3758.72.BJR - 2017 - 0172.R1。