Aziz Luaay, Saab Raya, Eid Toufic, Al-Abbadi Mousa A
Department of Ent and Head and Neck Surgery, Healthpoint Hospital, Abu Dhabi, United Arab Emirates.
Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
Avicenna J Med. 2018 Apr-Jun;8(2):58-62. doi: 10.4103/ajm.AJM_135_17.
We are reporting an unusual case of lymphoepithelial-like carcinoma (LELC) in an 8-year-old female patient where the tumor cells showed unusual CD4 expression. The lesion was found in the left submandibular neck region, in the vicinity of the submandibular gland. The salivary gland was not infiltrated by the tumor, and the tumor exhibited a classic LELC with single and clusters of tumor cells surrounded by many hematolymphoid cells. The tumor cells revealed strong positivity for Epstein-Bar virus as confirmed by the EBER: Epstein-Barr Virus in situ hybridization (EBER-ISH) method of staining. Interestingly, the tumor cells expressed membranous immunostaining for the T-helper lymphocyte antibody (CD4) in addition to pan-cytokeratin. A brief discussion about this unusual finding is offered. The patient was treated as a case of Epstein-Bar virus-associated nasopharyngeal carcinoma with excellent response.
我们报告了一例罕见的8岁女性淋巴上皮样癌（LELC）病例，该肿瘤细胞表现出异常的CD4表达。病变位于左下颌下颈部区域，靠近下颌下腺。唾液腺未被肿瘤浸润，肿瘤呈现典型的LELC，肿瘤细胞单个或成簇，周围有许多血液淋巴细胞。通过EBER：爱泼斯坦 - 巴尔病毒原位杂交（EBER-ISH）染色方法证实，肿瘤细胞对爱泼斯坦 - 巴尔病毒呈强阳性。有趣的是，除了全细胞角蛋白外，肿瘤细胞还表达T辅助淋巴细胞抗体（CD4）的膜免疫染色。本文对这一异常发现进行了简要讨论。该患者被作为爱泼斯坦 - 巴尔病毒相关鼻咽癌病例进行治疗，反应良好。
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