Wenig Bruce M
Department of Pathology, The Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York 10003.
Semin Diagn Pathol. 2015 Jan;32(1):74-86. doi: 10.1053/j.semdp.2014.12.004. Epub 2014 Dec 19.
Lymphoepithelial-like carcinomas (LELC) of the head and neck represent malignant neoplasms that are histologically similar to nasopharyngeal carcinoma (NPC), nonkeratinizing undifferentiated type but arise in locations other than the nasopharynx. The most common location for LELC in the head and neck is the salivary glands, in particular the parotid gland. However, LELC may arise in other sites including the oropharynx (tonsils, base of tongue), sinonasal tract, larynx, and middle ear/temporal bone. Unlike the nonkeratinizing undifferentiated type of NPC which is etiologically linked to Epstein-Barr virus (EBV), LELCs are not uniformly associated with EBV. The differential diagnosis for LELC varies per site and depending on the site of occurrence may include lymphoepithelial sialadenitis, sinonasal undifferentiated carcinoma (SNUC), and large cell neuroendocrine carcinoma. Treatment general includes combined (multimodality) therapy including surgical resection, neck dissection, radiation therapy and/or chemotherapy. The prognosis may vary per site overall favorable owing to a good response to therapy.
头颈部淋巴上皮样癌（LELC）是一种恶性肿瘤，在组织学上与鼻咽癌（NPC）、非角化未分化型相似，但发生于鼻咽以外的部位。头颈部LELC最常见的部位是唾液腺，尤其是腮腺。然而，LELC也可能发生在其他部位，包括口咽（扁桃体、舌根）、鼻窦、喉和中耳/颞骨。与病因与爱泼斯坦-巴尔病毒（EBV）相关的非角化未分化型NPC不同，LELC并非均与EBV相关。LELC的鉴别诊断因部位而异，根据发生部位可能包括淋巴上皮涎腺炎、鼻窦未分化癌（SNUC）和大细胞神经内分泌癌。治疗通常包括联合（多模式）治疗，包括手术切除、颈部清扫、放射治疗和/或化疗。由于对治疗反应良好，总体预后可能因部位而异，总体较为有利。
