Shift in rat liver glycolysis control from fed to starved conditions. Flux control coefficients of glucokinase and phosphofructokinase.

The distribution of flux control coefficients of a glycolytic system in starved rat liver has been determined. The flux control coefficient profile in starved conditions is compared with normal fed conditions showing that in the former phosphofructokinase enhances more than 2-fold its flux control coefficient while glucokinase decreases slightly. The results also show that the starved system has a more complex structure probably because of the greater influence on the flux of the reverse substrate cycles and the synthesis and degradation fructose 2,6-bisphosphate reactions.