葡萄糖激酶和磷酸果糖激酶对大鼠肝脏糖酵解的调控：葡萄糖浓度的影响
Control of glycolysis in rat liver by glucokinase and phosphofructokinase: influence of glucose concentration.
作者信息
Torres N V, Mateo F, Riol-Cimas J M, Meléndez-Hevia E
机构信息
Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de La Laguna, Canary Islands, Spain.
出版信息
Mol Cell Biochem. 1990 Mar 5;93(1):21-6. doi: 10.1007/BF00223488.
Control of glucose metabolism in rat liver under different glucose concentrations was studied. Flux Control Coefficients of glucokinase, glucose 6-phosphate isomerase and phosphofructokinase were determined by the 'shortening and enzyme titration' method. Results obtained show that glucose concentration in liver can play an important role in control of liver glycolysis by enhancing the Flux Control Coefficient of phosphofructokinase. Possible physiological significance of this fact is discussed.
研究了不同葡萄糖浓度下大鼠肝脏葡萄糖代谢的调控。通过“缩短和酶滴定”方法测定了葡萄糖激酶、葡萄糖 -6-磷酸异构酶和磷酸果糖激酶的通量控制系数。所得结果表明，肝脏中的葡萄糖浓度可通过提高磷酸果糖激酶的通量控制系数在肝脏糖酵解的调控中发挥重要作用。讨论了这一事实可能的生理意义。
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