Haddad Raad A, Alnimer Yanal, Abdalla Ahmed, Ríos-Bedoya Carlos F, Bachuwa Ghassan
1 Department of Internal Medicine, Hurley Medical Center, Michigan State University College of Human Medicine, Flint, MI, USA.
Clin Appl Thromb Hemost. 2018 Nov;24(8):1297-1300. doi: 10.1177/1076029618770289. Epub 2018 Apr 22.
Peripherally inserted central catheter (PICC) use is associated with many complications including line-related thrombosis. Several studies and meta-analyses confirmed the increased risk to develop venous thromboembolism in non-O blood group individuals. Our pilot study aimed to examine whether PICC-related thrombosis is influenced by ABO blood group. We identified patients admitted to Hurley Medical Center between March 2012 and March 2016 who had PICC placed during their admission, had their ABO blood group identified in their medical record, and had upper extremity venous Doppler ultrasound performed on the same side of PICC. We excluded pregnant women, patients on anticoagulation initiated before PICC insertion, and patients with active cancer. Data of 227 patients who met our criteria were analyzed. Of these patients, 140 (61.7%) patients had PICC-related thrombosis (cases) and 86 (37.9%) patients had O blood group. Controls were patients who had PICC and did not develop PICC-related thrombosis. Multivariate logistic regression revealed no association between PICC-related thrombosis and ABO blood group (adjusted odds ratio: 1.1; 95% confidence interval: 0.6-2.0; P = .733). Therefore, our data suggest that non-O blood group does not increase the odds of having PICC-related thrombosis.
经外周静脉穿刺中心静脉置管（PICC）的使用与包括导管相关血栓形成在内的许多并发症有关。多项研究和荟萃分析证实，非O血型个体发生静脉血栓栓塞的风险增加。我们的初步研究旨在探讨PICC相关血栓形成是否受ABO血型影响。我们确定了2012年3月至2016年3月期间入住赫尔利医疗中心的患者，这些患者在住院期间进行了PICC置管，其病历中记录了ABO血型，并在PICC同侧进行了上肢静脉多普勒超声检查。我们排除了孕妇、在PICC置管前开始抗凝治疗的患者以及患有活动性癌症的患者。对符合我们标准的227例患者的数据进行了分析。在这些患者中，140例（61.7%）发生了PICC相关血栓形成（病例组），86例（37.9%）为O血型。对照组为有PICC但未发生PICC相关血栓形成的患者。多因素逻辑回归显示，PICC相关血栓形成与ABO血型之间无关联（调整后的优势比：1.1；95%置信区间：0.6 - 2.0；P = 0.733）。因此，我们的数据表明，非O血型不会增加发生PICC相关血栓形成的几率。
