非肥胖阻塞性睡眠呼吸暂停患者的心外膜脂肪厚度与临床和多导睡眠图参数的相关性
Association of epicardial fat thickness with clinical and polysomnographic parameters in non-obese obstructive sleep apnoea patients.
作者信息
Derin S, Altun I, Koseoglu S, Sahin C, Yilmaz M, Akin F, Sahan M
机构信息
Department of Otorhinolaryngology,School of Medicine,Muğla Sıtkı Koçman University,Muğla,Turkey.
Department of Cardiology,School of Medicine,Muğla Sıtkı Koçman University,Muğla,Turkey.
出版信息
J Laryngol Otol. 2018 May;132(5):439-445. doi: 10.1017/S0022215118000579. Epub 2018 Apr 23.
OBJECTIVES
This study aimed to investigate the relationship of epicardial fat thickness with severity of obstructive sleep apnoea, and clinical and polysomnographic parameters, and to determine independent predictors for epicardial fat thickness.
METHODS
A total of 84 patients with a body mass index of less than 30 kg/m2 and suspected sleep-disordered breathing were included in the study. The correlations of epicardial fat thickness with polysomnographic and clinical data, and severity of obstructive sleep apnoea, were investigated.
RESULTS
Mean epicardial fat thickness was 3.75 ± 1.07 mm in the study group (n = 62) and 2.97 ± 0.62 mm in the control group (n = 22) (p < 0.001). There were significant positive correlations between epicardial fat thickness and: apnoea/hypopnoea index, oxygen desaturation index 3 and minimum oxygen saturation, as well as with age, body mass index, and neck and waist circumferences.
CONCLUSION
Non-obese obstructive sleep apnoea patients have thicker epicardial fat compared to controls. Oxygen desaturation index 3 has a strong correlation with epicardial fat thickness and is an independent predictor of it.
目的
本研究旨在探讨心外膜脂肪厚度与阻塞性睡眠呼吸暂停严重程度、临床及多导睡眠图参数之间的关系，并确定心外膜脂肪厚度的独立预测因素。
方法
本研究共纳入84例体重指数小于30kg/m²且疑似睡眠呼吸障碍的患者。研究了心外膜脂肪厚度与多导睡眠图和临床数据以及阻塞性睡眠呼吸暂停严重程度之间的相关性。
结果
研究组（n = 62）的心外膜脂肪平均厚度为3.75±1.07mm，对照组（n = 22）为2.97±0.62mm（p < 0.001）。心外膜脂肪厚度与以下指标之间存在显著正相关：呼吸暂停/低通气指数、氧去饱和指数3和最低氧饱和度，以及年龄、体重指数、颈围和腰围。
结论
与对照组相比，非肥胖阻塞性睡眠呼吸暂停患者的心外膜脂肪更厚。氧去饱和指数3与心外膜脂肪厚度密切相关，是其独立预测因素。
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