School of Nursing, University of Texas at Austin, Austin, TX, USA.
University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Psychooncology. 2018 Aug;27(8):1937-1943. doi: 10.1002/pon.4745. Epub 2018 May 25.
Links have been made between aspects of sleep quality and cognitive function in breast cancer survivors (BCS), but findings are heterogeneous. The objective of this study is to examine relationships between specific sleep quality components (latency, duration, efficiency, daytime sleepiness, sleep disturbance, use of sleep aids) and cognitive impairment (performance and perceived), and determine which sleep quality components are the most significant contributors to cognitive impairments in BCS 6 months to 10 years post chemotherapy.
Women 21 to 65 years old with a history of non-metastatic breast cancer following chemotherapy completion were recruited. Data collection included surveys to evaluate sleep quality and perceived cognitive impairments, and neuropsychological testing to evaluate verbal fluency and memory. Descriptive statistics, bivariate correlations, and hierarchical multiple regression were calculated.
Ninety women (mean age 49) completed data collection. Moderate significant correlations were found between daytime dysfunction, sleep efficiency, sleep latency, and sleep disturbance and perceived cognitive impairment (Rs = -0.37 to -0.49, Ps < .00049), but not objective cognitive performance of verbal fluency, memory, or attention. After accounting for individual and clinical characteristics, the strongest predictors of perceived cognitive impairments were daytime dysfunction, sleep efficiency, and sleep disturbance.
Findings support links between sleep quality and perceived cognitive impairments in BCS and suggest specific components of sleep quality (daytime dysfunction, sleep efficiency, and sleep disturbance) are associated with perceived cognitive functioning in this population. Findings can assist clinicians in guiding survivors to manage sleep and cognitive problems and aid in the design of interventional research.
已经发现乳腺癌幸存者（BCS）的睡眠质量和认知功能之间存在关联，但研究结果存在异质性。本研究旨在探讨特定睡眠质量成分（潜伏期、持续时间、效率、日间嗜睡、睡眠障碍、使用助眠剂）与认知障碍（表现和感知）之间的关系，并确定哪些睡眠质量成分是导致 BCS 在化疗后 6 个月至 10 年内认知障碍的最重要因素。
招募了年龄在 21 至 65 岁之间、化疗后患有非转移性乳腺癌病史的女性。数据收集包括评估睡眠质量和感知认知障碍的调查，以及评估言语流畅性和记忆的神经心理学测试。计算了描述性统计、双变量相关性和分层多元回归。
90 名女性（平均年龄 49 岁）完成了数据收集。日间功能障碍、睡眠效率、睡眠潜伏期和睡眠障碍与感知认知障碍之间存在中度显著相关性（Rs=-0.37 至-0.49，P<.00049），但与言语流畅性、记忆或注意力等客观认知表现无关。在考虑个体和临床特征后，日间功能障碍、睡眠效率和睡眠障碍是感知认知障碍的最强预测因素。
研究结果支持 BCS 睡眠质量与感知认知障碍之间的关联，并表明睡眠质量的特定成分（日间功能障碍、睡眠效率和睡眠障碍）与该人群的感知认知功能相关。这些发现可以帮助临床医生指导幸存者管理睡眠和认知问题，并为干预性研究的设计提供帮助。
