昼夜节律、激素节律和睡眠节律：对癌症进展的影响及治疗意义。
Circadian, hormonal, and sleep rhythms: effects on cancer progression implications for treatment.
作者信息
Jagielo Annemarie D, Benedict Catherine, Spiegel David
机构信息
PGSP-Stanford Psy.D. Consortium, Palo Alto University, Palo Alto, CA, United States.
Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, CA, Stanford, CA, United States.
出版信息
Front Oncol. 2023 Sep 7;13:1269378. doi: 10.3389/fonc.2023.1269378. eCollection 2023.
Circadian, hormonal, and sleep rhythm disruptions are commonly experienced concerns among cancer patients throughout the cancer care continuum. This review aims to summarize the existing literature on circadian, hormonal, and sleep rhythms in the oncological population, focusing on circadian disruption and physiological and psychological abnormalities, disease progression, and chronomodulated treatment approaches. The findings demonstrate that subjectively and objectively measured circadian rhythm disruption is associated with adverse mental health and disease outcomes in patients with cancer. Chronomodulated chemotherapy, light therapy, cognitive behavioral therapy for insomnia, and physical activity have shown evidence of effectiveness in improving sleep, and occasionally, disease outcomes.
昼夜节律、激素和睡眠节律紊乱是癌症患者在整个癌症治疗过程中普遍面临的问题。本综述旨在总结肿瘤患者中有关昼夜节律、激素和睡眠节律的现有文献，重点关注昼夜节律紊乱以及生理和心理异常、疾病进展和时辰调节治疗方法。研究结果表明，主观和客观测量的昼夜节律紊乱与癌症患者的不良心理健康和疾病结局相关。时辰调节化疗、光疗、失眠认知行为疗法和体育活动已显示出改善睡眠的有效性证据，偶尔也能改善疾病结局。
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