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LY121019 inhibits Neurospora crassa growth and (1-3)-beta-D-glucan synthase.

作者信息

Taft C S, Selitrennikoff C P

机构信息

Department of Cellular & Structural Biology, University of Colorado Health Sciences Center, Denver 80262.

出版信息

J Antibiot (Tokyo). 1988 May;41(5):697-701. doi: 10.7164/antibiotics.41.697.

DOI:10.7164/antibiotics.41.697
PMID:2968332
Abstract
摘要

相似文献

1
LY121019 inhibits Neurospora crassa growth and (1-3)-beta-D-glucan synthase.
J Antibiot (Tokyo). 1988 May;41(5):697-701. doi: 10.7164/antibiotics.41.697.
2
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In vitro inhibition of stable 1,3-beta-D-glucan synthase activity from Neurospora crassa.体外抑制粗糙脉孢菌稳定的1,3-β-D-葡聚糖合酶活性。
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Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity.西洛芬净（LY121019）可抑制白色念珠菌（1-3）-β-D-葡聚糖合酶的活性。
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Inhibition of Neurospora crassa growth by a glucan synthase-1 antisense construct.葡聚糖合酶-1反义构建体对粗糙脉孢菌生长的抑制作用。
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Use of a temperature-sensitive, protoplast-forming Neurospora crassa strain for the detection of antifungal antibiotics.使用一种温度敏感型、可形成原生质体的粗糙脉孢菌菌株来检测抗真菌抗生素。
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Echinocandin inhibition of 1,3-beta-D-glucan synthase from Candida albicans.棘白菌素对白色念珠菌1,3-β-D-葡聚糖合酶的抑制作用。
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Characterization and cilofungin inhibition of solubilized Aspergillus fumigatus (1,3)-beta-D-glucan synthase.溶解态烟曲霉（1,3）-β-D-葡聚糖合酶的特性及西洛芬净对其的抑制作用
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Compounds active against cell walls of medically important fungi.对医学上重要真菌的细胞壁具有活性的化合物。
Clin Microbiol Rev. 1993 Jan;6(1):1-21. doi: 10.1128/CMR.6.1.1.
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Characterization and cilofungin inhibition of solubilized Aspergillus fumigatus (1,3)-beta-D-glucan synthase.溶解态烟曲霉（1,3）-β-D-葡聚糖合酶的特性及西洛芬净对其的抑制作用
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3
Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase.
脂肽对烟曲霉的形态学影响与对（1,3）-β-D-葡聚糖合酶的活性相关。
Antimicrob Agents Chemother. 1994 Jul;38(7):1480-9. doi: 10.1128/AAC.38.7.1480.
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Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.水溶性半合成肺念珠菌素L-733,560的抗真菌活性增强，这是由于其对细胞壁合成的抑制作用增强所致。
Antimicrob Agents Chemother. 1994 Dec;38(12):2750-7. doi: 10.1128/AAC.38.12.2750.
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Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.气雾剂和肠胃外给予的棘白菌素类药物在大鼠肺曲霉病模型中有效。
Antimicrob Agents Chemother. 1995 Aug;39(8):1784-9. doi: 10.1128/AAC.39.8.1784.
6
Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity.西洛芬净（LY121019）可抑制白色念珠菌（1-3）-β-D-葡聚糖合酶的活性。
Antimicrob Agents Chemother. 1988 Dec;32(12):1901-3. doi: 10.1128/AAC.32.12.1901.
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Efficacy of cilofungin alone and in combination with amphotericin B in a murine model of disseminated aspergillosis.西洛芬净单独及与两性霉素B联合应用于播散性曲霉病小鼠模型的疗效
Antimicrob Agents Chemother. 1991 Jul;35(7):1329-33. doi: 10.1128/AAC.35.7.1329.
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Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-beta-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis.在治疗实验性播散性念珠菌病时，1,3-β-葡聚糖合成酶抑制剂西洛芬净连续和间歇静脉输注期间的非线性药代动力学的抗真菌作用。
Antimicrob Agents Chemother. 1991 Jul;35(7):1321-8. doi: 10.1128/AAC.35.7.1321.
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W-1 solubilization and kinetics of inhibition by cilofungin of Candida albicans (1,3)-beta-D-glucan synthase.W-1对白色念珠菌（1,3）-β-D-葡聚糖合酶的溶解作用及西洛芬净的抑制动力学
Antimicrob Agents Chemother. 1991 Jan;35(1):99-103. doi: 10.1128/AAC.35.1.99.