a Surgical Oncology Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
b Department of Basic Medical Sciences , Neyshabur University of Medical Sciences , Neyshabur , Iran.
Drug Chem Toxicol. 2019 Sep;42(5):536-540. doi: 10.1080/01480545.2018.1459673. Epub 2018 Apr 23.
The present study aimed to evaluate serum prooxidant -antioxidant balance (PAB) in an Iranian population exposed to sulfur mustard (SM) more than 20 years ago. In this study, 42 SM-exposed subjects and 30 unexposed subjects (as controls) were recruited. Serum PAB, biochemical, and hematological parameters were measured in all subjects. Correlation of PAB with biochemical and hematological parameters was determined. The mean PAB values in the SM-exposed group (82.5 ± 34.8 HK) were significantly higher than that in the control group [47.5 ± 17.8 HK] ( < 0.001). The results demonstrated that serum PAB values were positively correlated with alkaline phosphatase activities in the SM-exposed group. Furthermore, PAB values showed a significant negative correlation with hepatic enzymes (AST, ALT), triglycerides, total bilirubin, and mean corpuscular hemoglobin concentrations. PAB values showed a borderline significant negative correlation with uric acid. The present results suggest that late oxidative stress and alterations in biochemical and hematological parameters may be a consequence of the frequent respiratory infections rather than direct toxic effects of SM.
本研究旨在评估 20 多年前接触过硫芥（SM）的伊朗人群的血清促氧化剂-抗氧化剂平衡（PAB）。在这项研究中，招募了 42 名 SM 暴露受试者和 30 名未暴露受试者（作为对照）。所有受试者均测量了血清 PAB、生化和血液学参数。确定了 PAB 与生化和血液学参数的相关性。暴露于 SM 组的平均 PAB 值（82.5 ± 34.8 HK）明显高于对照组[47.5 ± 17.8 HK]（<0.001）。结果表明，SM 暴露组的血清 PAB 值与碱性磷酸酶活性呈正相关。此外，PAB 值与肝酶（AST、ALT）、甘油三酯、总胆红素和平均红细胞血红蛋白浓度呈显著负相关。PAB 值与尿酸呈边缘显著负相关。本研究结果表明，晚期氧化应激和生化及血液学参数的改变可能是频繁呼吸道感染的后果，而不是 SM 的直接毒性作用。
