Poli T, Lapolla A, Pelli B, Sturaro A, Traldi P, Crepaldi G, Fedele D
Istituto di Medicina Interna, Patologia Medica I., Policlinico Universitario, Padova, Italy.
J Diabet Complications. 1988 Jan-Mar;2(1):25-6. doi: 10.1016/0891-6632(88)90023-2.
The build-up of brown products on long-lived proteins could be an important factor in determining long-term diabetic complications. A brown product 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI), present in the acid hydrolysate mixtures of beta-polylysine and beta-albumin has been identified by collisional spectroscopy, using a commercial double-focusing, reverse-geometry mass spectrometer. Using this approach the analyses were carried out without any sample derivatization or need for chromatographic separation procedures.
长寿蛋白上棕色产物的积累可能是决定长期糖尿病并发症的一个重要因素。通过使用商用双聚焦反几何质谱仪的碰撞光谱法，已鉴定出存在于β-聚赖氨酸和β-白蛋白酸水解混合物中的一种棕色产物2-(2-糠酰基)-4(5)-(2-呋喃基)-1H-咪唑(FFI)。采用这种方法进行分析时无需任何样品衍生化或色谱分离程序。
