Hoff A L, Shukla S, Cook B L, Aronson T A, Ollo C L, Pass H L
Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8101.
J Affect Disord. 1988 May-Jun;14(3):251-5. doi: 10.1016/0165-0327(88)90042-0.
Researchers studying cognition in mania have assumed that mania is a homogeneous entity. Recent preliminary evidence indicates that some manic syndromes may be preceded by medical, pharmacological, and neurologic antecedents. While DSM-III suggests that mild cognitive impairment may be associated with these manic syndromes, studies to date have not documented this assertion. We compared bipolar patients with antecedent neurologic factors (neurologic manics, NM) to bipolar patients without such histories (primary manics, PM) on standard neuropsychological measures and clinical parameters to ascertain whether cognitive testing could be used as an adjunctive diagnostic tool in defining this subgroup of patients. Results indicated that the NM group was more dysfunctional in intellectual functioning and course of psychiatric illness than the PM group.
研究躁狂症认知的研究人员一直假定躁狂症是一个同质的实体。最近的初步证据表明，一些躁狂综合征可能有医学、药理学和神经学方面的前驱因素。虽然《精神疾病诊断与统计手册》第三版表明轻度认知障碍可能与这些躁狂综合征有关，但迄今为止的研究尚未证实这一论断。我们将有前驱神经学因素的双相情感障碍患者（神经学性躁狂症患者，NM）与无此类病史的双相情感障碍患者（原发性躁狂症患者，PM）进行了标准神经心理学测量和临床参数的比较，以确定认知测试是否可作为一种辅助诊断工具来界定这一亚组患者。结果表明，NM组在智力功能和精神疾病病程方面比PM组功能更差。
