在对Mlsa编码抗原进行新生期耐受诱导过程中，胸腺内对Mlsa反应性（Vβ6 +）细胞的清除。
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.
作者信息
MacDonald H R, Pedrazzini T, Schneider R, Louis J A, Zinkernagel R M, Hengartner H
机构信息
Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
出版信息
J Exp Med. 1988 Jun 1;167(6):2005-10. doi: 10.1084/jem.167.6.2005.
Abstract
The cellular basis of neonatally induced T cell tolerance has been investigated in a model system in which usage of a particular TCR V beta segment (V beta 6) is strongly correlated with reactivity to antigens encoded by the Mlsa genetic locus. Expression of V beta 6 by peripheral T cells was virtually abolished in BALB/c (H-2d, Mlsb) mice rendered neonatally tolerant to DBA/2 (H-2d, Mlsa) lymphoid cells, whereas control V beta 8-bearing T cells remained at near normal levels. Further analysis revealed that elimination of V beta 6+ T cells occurred in the thymus of neonatally tolerant mice and could not be explained by receptor modulation or T cell chimerism. These data thus support the clonal deletion model of tolerance induction.
摘要
在一个模型系统中研究了新生期诱导的T细胞耐受性的细胞基础，在该系统中，特定TCR Vβ片段（Vβ6）的使用与对由Mlsa基因座编码的抗原的反应性密切相关。在新生期对DBA/2（H-2d，Mlsa）淋巴细胞产生耐受性的BALB/c（H-2d，Mlsb）小鼠中，外周T细胞Vβ6的表达几乎被消除，而对照的携带Vβ8的T细胞仍维持在接近正常的水平。进一步分析表明，新生期耐受小鼠的胸腺中发生了Vβ6+ T细胞的清除，这不能用受体调节或T细胞嵌合现象来解释。因此，这些数据支持耐受性诱导的克隆清除模型。
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本文引用的文献
1
Thymocyte rosettes: multicellular complexes of lymphocytes and bone marrow-derived stromal cells in the mouse thymus.胸腺细胞玫瑰花结：小鼠胸腺中淋巴细胞与骨髓来源基质细胞形成的多细胞复合体。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5646-50. doi: 10.1073/pnas.79.18.5646.
2
Intrathymic presentation of circulating non-major histocompatibility complex antigens.循环中非主要组织相容性复合体抗原的胸腺内呈递。
Nature. 1984;308(5955):196-9. doi: 10.1038/308196a0.
3
Cellular mechanisms of immunologic tolerance.免疫耐受的细胞机制。
Annu Rev Immunol. 1983;1:33-62. doi: 10.1146/annurev.iy.01.040183.000341.
4
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.T细胞上抗原特异性、主要组织相容性复合体限制的受体。VI. 针对受体同种异型的抗体。
J Exp Med. 1984 Aug 1;160(2):452-71. doi: 10.1084/jem.160.2.452.
5
Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.胸腺中产生T细胞生长因子细胞的前体：由单克隆抗体GK-1.5定义的表型成熟胸腺细胞亚群中的个体发生、频率及定量回收
J Exp Med. 1983 Nov 1;158(5):1654-71. doi: 10.1084/jem.158.5.1654.
6
Interleukin 2 production by lymphoid cells from congenitally athymic (nu/nu) mice.先天性无胸腺（裸/裸）小鼠的淋巴细胞产生白细胞介素2 。
J Immunol. 1982 Aug;129(2):521-5.
7
Immunological unresponsiveness.免疫无反应性
Adv Immunol. 1973;16:61-122. doi: 10.1016/s0065-2776(08)60296-5.
8
T cell tolerance by clonal elimination in the thymus.胸腺中通过克隆清除实现的T细胞耐受性。
Cell. 1987 Apr 24;49(2):273-80. doi: 10.1016/0092-8674(87)90568-x.
9
The peptidic self model: a hypothesis on the molecular nature of the immunological self.肽性自身模型：关于免疫自身分子本质的一种假说。
Ann Inst Pasteur Immunol. 1986 Jul-Aug;137D(1):3-21.
10
A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product.一种赋予对II类主要组织相容性复合体产物反应性的T细胞受体Vβ区段。
Cell. 1987 Apr 24;49(2):263-71. doi: 10.1016/0092-8674(87)90567-8.
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