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单中心气管支气管成形术治疗气管支气管软化症的经验:围手术期结果。

Single-Center Experience of Tracheobronchoplasty for Tracheobronchomalacia: Perioperative Outcomes.

机构信息

Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

出版信息

Ann Thorac Surg. 2018 Sep;106(3):909-915. doi: 10.1016/j.athoracsur.2018.03.043. Epub 2018 Apr 21.

Abstract

BACKGROUND

We present trends in practice as our experience has grown and report the postoperative morbidity and its associated factors after tracheobronchoplasty.

METHODS

A retrospective cohort study was conducted of 161 patients who underwent tracheobronchoplasty from October 2002 to September 2016. The main outcome was development of a postoperative complication within 30 days of the operation. Postoperative complication events were graded using the Clavien-Dindo system. The study patients were divided into two consecutive cohorts to examine trends in systems of care. Postoperative morbidity was examined using a log-binomial regression model.

RESULTS

The cohort consisted of 103 women (64%), with a median age of 58 years (interquartile range, 52 to 66 years). Postoperative morbidity occurred in 75 patients (47%). Severe complications (Clavien-Dindo grade ≥IIIa) occurred in 38 patients (24%), most of which were respiratory in nature, including 27 (17%) with respiratory failure. Median intensive care unit length of stay was 4 days (interquartile range, 3 to 5 days), with a total length of stay of 8 days (interquartile range, 6 to 11 days). In-hospital mortality occurred in 2 patients (1%). Discharge was directly to home in 68% of patients (37% without assistance and 31% with visiting nurse follow-up) and to a rehabilitation facility in 31%. After adjusting for age, sex, race, operative time, and intraoperative blood loss, forced expiratory volume in 1 second was an independent predictor (odds ratio, 0.97; 95% confidence interval, 0.95 to 0.99; p = 0.01) for postoperative morbidity.

CONCLUSIONS

Despite an arduous hospital course with significant risk of severe complication, patients undergoing tracheobronchoplasty for severe tracheobronchomalacia have low risk of mortality and most are discharged directly to home.

摘要

背景

随着经验的积累,我们展示了实践中的趋势,并报告了气管支气管成形术后的发病率及其相关因素。

方法

对 2002 年 10 月至 2016 年 9 月期间接受气管支气管成形术的 161 例患者进行了回顾性队列研究。主要结果是术后 30 天内发生术后并发症。术后并发症事件采用 Clavien-Dindo 系统分级。研究患者分为两个连续队列,以检查护理系统的趋势。使用对数二项式回归模型检查术后发病率。

结果

该队列包括 103 名女性(64%),中位年龄为 58 岁(四分位距,52 至 66 岁)。75 例患者(47%)发生术后发病率。严重并发症(Clavien-Dindo 分级≥IIIa)发生在 38 例患者(24%)中,大多数为呼吸系统,其中 27 例(17%)发生呼吸衰竭。重症监护病房住院时间中位数为 4 天(四分位距,3 至 5 天),总住院时间为 8 天(四分位距,6 至 11 天)。2 例患者(1%)发生院内死亡。68%的患者直接出院回家(37%无需协助,31%有随访护士),31%的患者出院至康复设施。调整年龄、性别、种族、手术时间和术中失血量后,用力呼气量是术后发病率的独立预测因素(优势比,0.97;95%置信区间,0.95 至 0.99;p=0.01)。

结论

尽管气管支气管成形术治疗严重气管支气管软化症的患者具有艰难的住院过程和严重并发症的高风险,但死亡率低,大多数患者直接出院回家。

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