长链非编码 RNA 的特征分析揭示肝癌潜在的预后生物标志物。
Characterization of long non-coding RNAs to reveal potential prognostic biomarkers in hepatocellular carcinoma.
机构信息
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 200241 Shanghai, China; Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 200241 Shanghai, China.
出版信息
Gene. 2018 Jul 15;663:148-156. doi: 10.1016/j.gene.2018.04.053. Epub 2018 Apr 21.
Dysregulation of long non-coding RNAs (lncRNAs) plays critical roles in a variety of biological processes. Recent studies have documented that lncRNAs can function as potential biomarkers in cancer prognosis, however, little is known in hepatocellular carcinoma (HCC). To identify lncRNA signatures that have prognostic values in HCC, we analyzed lncRNA expression profiles of 364 HCC patients from The Cancer Genome Atlas (TCGA) dataset. A set of four lncRNAs was identified to be significantly associated with the overall survival. Based on the four-lncRNA signature, HCC patients can be classified into high- and low-risk subgroups with significantly different survival. This result can be further validated in the testing set and another independent HCC data. Further analyses showed that the prognostic value of four-lncRNA signature was independent of other clinicopathological factors. The potential functions of candidate lncRNAs were further examined using HCC cell lines, suggesting these lncRNAs might contribute to tumor development of HCC. This work indicated that lncRNA signature could be a useful marker to determine the diagnosis and predict the prognosis of HCC.
长链非编码 RNA（lncRNA）的失调在多种生物学过程中起着关键作用。最近的研究表明，lncRNA 可以作为癌症预后的潜在生物标志物，然而，在肝细胞癌（HCC）中知之甚少。为了确定 lncRNA 特征在 HCC 中的预后价值，我们分析了来自癌症基因组图谱（TCGA）数据集的 364 名 HCC 患者的 lncRNA 表达谱。一组四个 lncRNA 被确定与总生存率显著相关。基于这四个 lncRNA 特征，HCC 患者可以根据生存情况分为高风险和低风险亚组，两组之间的生存情况存在显著差异。这一结果可以在测试集和另一个独立的 HCC 数据中进一步验证。进一步的分析表明，四个 lncRNA 特征的预后价值独立于其他临床病理因素。通过 HCC 细胞系进一步研究候选 lncRNA 的潜在功能，表明这些 lncRNA 可能有助于 HCC 的肿瘤发展。这项工作表明，lncRNA 特征可以作为一种有用的标志物来确定 HCC 的诊断和预测预后。
Zotero 插件