Goyal Himanshi, Parwani Sachin, Kaur Jyotdeep
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Cell Death Discov. 2024 Oct 24;10(1):451. doi: 10.1038/s41420-024-02200-2.
Hepatocellular carcinoma (HCC) remains a significant global health challenge with few effective treatment options. The dysregulation of endoplasmic reticulum (ER) stress responses has emerged as a pivotal factor in HCC progression and therapy resistance. Long non-coding RNAs (lncRNAs) play a crucial role as key epigenetic modifiers in this process. Recent research has explored how lncRNAs influence ER stress which in turn affects lncRNAs activity in HCC. We systematically analyze the current literature to highlight the regulatory roles of lncRNAs in modulating ER stress and vice versa in HCC. Our scrutinization highlights how dysregulated lncRNAs contribute to various facets of HCC, including apoptosis resistance, enhanced proliferation, invasion, and metastasis, all driven by ER stress. Moreover, we delve into the emerging paradigm of the lncRNA-miRNA-mRNA axis, elucidating it as the promising avenue for developing novel biomarkers and paving the way for more personalized treatment options in HCC. Nevertheless, we acknowledge the challenges and future directions in translating these insights into clinical practice. In conclusion, our review provides insights into the complex regulatory mechanisms governing ER stress modulation by lncRNAs in HCC.
肝细胞癌（HCC）仍然是一项重大的全球健康挑战，有效的治疗选择很少。内质网（ER）应激反应失调已成为HCC进展和治疗耐药的关键因素。长链非编码RNA（lncRNAs）在这一过程中作为关键的表观遗传修饰因子发挥着至关重要的作用。最近的研究探讨了lncRNAs如何影响内质网应激，而内质网应激又反过来影响HCC中lncRNAs的活性。我们系统地分析了当前的文献，以突出lncRNAs在调节内质网应激中的作用，反之亦然在HCC中的作用。我们的审查突出了lncRNAs失调如何导致HCC的各个方面，包括抗凋亡、增殖增强、侵袭和转移，所有这些都是由内质网应激驱动的。此外，我们深入探讨了lncRNA-miRNA-mRNA轴这一新兴范式，阐明它是开发新型生物标志物的有前途的途径，并为HCC中更个性化的治疗选择铺平道路。然而，我们认识到将这些见解转化为临床实践中的挑战和未来方向。总之，我们的综述提供了对HCC中lncRNAs调节内质网应激的复杂调控机制的见解。
