Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, ul. Postepu 36A, Jastrzębiec, 05-552 Magdalenka, Poland; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria; Institute of Clinical Chemistry, University Hospital Zurich, Wagistrasse 14, 8952 Schlieren, Switzerland.
Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria.
Biotechnol Adv. 2018 Nov 1;36(6):1586-1607. doi: 10.1016/j.biotechadv.2018.04.006. Epub 2018 Apr 21.
Cardiovascular diseases are a major cause of human death worldwide. Excessive proliferation of vascular smooth muscle cells contributes to the etiology of such diseases, including atherosclerosis, restenosis, and pulmonary hypertension. The control of vascular cell proliferation is complex and encompasses interactions of many regulatory molecules and signaling pathways. Herein, we recapitulated the importance of signaling cascades relevant for the regulation of vascular cell proliferation. Detailed understanding of the mechanism underlying this process is essential for the identification of new lead compounds (e.g., natural products) for vascular therapies.
心血管疾病是全球人类死亡的主要原因。血管平滑肌细胞的过度增殖导致了这些疾病的发生，包括动脉粥样硬化、再狭窄和肺动脉高压。血管细胞增殖的控制是复杂的，涉及许多调节分子和信号通路的相互作用。在此，我们总结了与血管细胞增殖调节相关的信号级联的重要性。详细了解这一过程的机制对于鉴定新的血管治疗先导化合物（如天然产物）至关重要。
