Braun-Dullaeus R C, Mann M J, Dzau V J
Cardiovascular Research, Brigham and Women's Hospital, Boston, Mass 02115, USA.
Circulation. 1998 Jul 7;98(1):82-9. doi: 10.1161/01.cir.98.1.82.
Entry into and progression of vascular cells through the cell cycle is considered a key event in vascular proliferative diseases. Multiple growth factors and cytokines have been found to regulate vascular cell proliferation. However, the machinery regulating cell cycle represents the "final common pathway" of these signaling cascades and thus provides an attractive therapeutic target for the prevention of vascular proliferative diseases. This review focuses on the current understanding of the regulation of the cell cycle machinery especially as it relates to vascular cell biology and the feasibility of targeting cell cycle for the prevention of restenosis after balloon angioplasty and bypass vein graft disease.
血管细胞进入细胞周期并在其中进展被认为是血管增殖性疾病中的关键事件。已发现多种生长因子和细胞因子可调节血管细胞增殖。然而，调节细胞周期的机制代表了这些信号级联反应的“最终共同途径”，因此为预防血管增殖性疾病提供了一个有吸引力的治疗靶点。本综述重点关注目前对细胞周期机制调节的理解，特别是其与血管细胞生物学的关系，以及针对细胞周期预防球囊血管成形术后再狭窄和旁路静脉移植疾病的可行性。
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