Reed M J, Lai L C, Ghilchik M W, James V H
Department of Chemical Pathology, St Mary's Hospital Medical School, London, England.
J Steroid Biochem. 1988;30(1-6):489-92. doi: 10.1016/0022-4731(88)90150-1.
We have examined the effect of co-administration of dehydroepiandrosterone sulphate, 5-androstenediol or cortisol on the metabolic clearance rate of oestradiol (MCR-E2) and conversion of oestradiol to oestrone (CRE2E1). Previous studies have shown that these androgens influence the metabolism of oestradiol in vitro while cortisol alters the distribution of oestradiol in plasma. The MCR-E2 and CRE2E1 were measured after 2.5 and 5 h of [3H]oestradiol infusion with co-infusion of androgen or cortisol starting after 2.5 h of tracer infusion. For one subject who did not receive co-infusion of another steroid no significant change in MCR-E2 or CRE2E1 occurred over the 5-h period. For other subjects, however, the MCR-E2 decreased by 18 +/- 7% (mean +/- SD) while the CRE2E1 increased by 45 +/- 12%. It is possible that these results are due to: changes in the distribution of oestradiol in plasma; differences in the metabolism of oestradiol bound to albumin or SHBG, or an effect of androgens or cortisol on the uptake of [3H]oestradiol by the liver.
我们研究了硫酸脱氢表雄酮、5-雄烯二醇或皮质醇共同给药对雌二醇代谢清除率（MCR-E2）以及雌二醇向雌酮转化（CRE2E1）的影响。先前的研究表明，这些雄激素在体外会影响雌二醇的代谢，而皮质醇会改变血浆中雌二醇的分布。在注入[3H]雌二醇2.5小时后开始共同注入雄激素或皮质醇，并在注入示踪剂2.5小时和5小时后测量MCR-E2和CRE2E1。对于一名未共同注入其他类固醇的受试者，在5小时内MCR-E2或CRE2E1未发生显著变化。然而，对于其他受试者，MCR-E2下降了18±7%（平均值±标准差），而CRE2E1上升了45±12%。这些结果可能是由于：血浆中雌二醇分布的变化；与白蛋白或性激素结合球蛋白结合的雌二醇代谢差异，或雄激素或皮质醇对肝脏摄取[3H]雌二醇的影响。
