柳氮磺胺吡啶是前列腺素15-羟基脱氢酶的强效抑制剂：可能是溃疡性结肠炎治疗作用的基础。
Sulphasalazine is a potent inhibitor of prostaglandin 15-hydroxydehydrogenase: possible basis for therapeutic action in ulcerative colitis.
作者信息
Hoult J R, Moore P K
出版信息
Br J Pharmacol. 1978 Sep;64(1):6-8. doi: 10.1111/j.1476-5381.1978.tb08633.x.
Abstract
Sulphasalazine is a potent and selective inhibitor in vitro of prostaglandin 15-hydroxydehydrogenase in rabbit colon (ID50 = 50 micrometer) and in several other organs of different species, but does not inhibit prostaglandin delta-13 reductase or microsomal prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of relapse.
摘要
柳氮磺胺吡啶在体外是兔结肠中前列腺素15 - 羟基脱氢酶的强效选择性抑制剂（半数抑制浓度=50微摩尔），在其他几种不同物种的器官中也是如此，但它不抑制前列腺素δ-13还原酶或花生四烯酸的微粒体前列腺素合成。有人认为，这一作用可能是柳氮磺胺吡啶在溃疡性结肠炎预防复发方面具有治疗作用的基础。
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PREDNISONE AS MAINTENANCE TREATMENT FOR ULCERATIVE COLITIS IN REMISSION.泼尼松作为溃疡性结肠炎缓解期的维持治疗药物。
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Drugs which inhibit prostaglandin biosynthesis.抑制前列腺素生物合成的药物。
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Effects of some naturally occurring prostaglandins and synthetic analogues on gastric secretion and ulcer healing in man.某些天然存在的前列腺素及其合成类似物对人体胃液分泌及溃疡愈合的影响。
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Drug therapy: Sulfasalazine.药物治疗：柳氮磺胺吡啶。
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