急性溃疡性结肠炎中前列腺素合成酶活性：柳氮磺胺吡啶、磷酸可待因及泼尼松龙治疗的效果
Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone.
作者信息
Smith P R, Dawson D J, Swan C H
出版信息
Gut. 1979 Sep;20(9):802-5. doi: 10.1136/gut.20.9.802.
Abstract
Prostaglandin synthetase activity in rectal biopsy specimens from patients with ulcerative colitis has been shown to fall on treatment with sulphasalazine, local steroids, and codeine phosphate. In vitro studies have shown that sulphasalazine is an inhibitor of prostaglandin synthetase, although less potent than indomethacin, whereas prednisolone and codeine phosphate were inactive. It is suggested that the therapeutic action of sulphasalazine may be related in part to its action in inhibiting prostaglandin biosynthesis.
摘要
溃疡性结肠炎患者直肠活检标本中的前列腺素合成酶活性已被证明在接受柳氮磺胺吡啶、局部类固醇和磷酸可待因治疗后会下降。体外研究表明，柳氮磺胺吡啶是前列腺素合成酶的抑制剂，尽管其效力不如吲哚美辛，而泼尼松龙和磷酸可待因则无活性。有人提出，柳氮磺胺吡啶的治疗作用可能部分与其抑制前列腺素生物合成的作用有关。
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