Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Department of Pediatrics, Università degli Studi, Pavia, Italy.
J Biol Regul Homeost Agents. 2018 Mar-Apr;32(2):335-339.
Several experimental studies in mice showed that basophils participate in the initiation of Th2 adaptive immune response, in addition to the effector phase. However, the role of basophils in allergic airway inflammation is less clear. The aim of this experiment was to assess the importance of basophils in recruiting inflammatory cells and, in particular, eosinophils in a murine model of asthma induced by Aspergillus fumigatus allergens. Additionally, bronchial reactivity was evaluated. Basophil depletion resulted in a reduction of inflammatory cells in the airways and eosinophil recruitment was significantly impaired. Also bronchial reactivity seemed to be impaired in basophil-depleted mice, but the result was not statistically significant. According to these preliminary data, basophils seem to influence the local eosinophilic response of allergic asthma.
几项在小鼠中的实验研究表明，嗜碱性粒细胞除了在效应阶段参与 Th2 适应性免疫反应的启动外，还参与其中。然而，嗜碱性粒细胞在过敏性气道炎症中的作用尚不清楚。本实验旨在评估嗜碱性粒细胞在招募炎症细胞（特别是嗜酸性粒细胞）方面的重要性，在烟曲霉过敏原诱导的哮喘小鼠模型中进行了评估。此外，还评估了支气管反应性。嗜碱性粒细胞耗竭导致气道中的炎症细胞减少，嗜酸性粒细胞募集明显受损。此外，嗜碱性粒细胞耗竭小鼠的支气管反应性似乎也受到损害，但结果无统计学意义。根据这些初步数据，嗜碱性粒细胞似乎影响过敏性哮喘的局部嗜酸性粒细胞反应。
