McLane M P, Haczku A, van de Rijn M, Weiss C, Ferrante V, MacDonald D, Renauld J C, Nicolaides N C, Holroyd K J, Levitt R C
Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, PA 19462, USA.
Am J Respir Cell Mol Biol. 1998 Nov;19(5):713-20. doi: 10.1165/ajrcmb.19.5.3457.
Human atopic asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of allergic inflammation and airway hyperresponsiveness. Recent studies demonstrate that the degree of airway responsiveness is strongly associated with interleukin (IL)-9 expression in murine lung. To investigate the contribution of IL-9 to airway hyperresponsiveness, and to explore directly its relationship to airway inflammation, we studied transgenic mice overexpressing IL-9. In this report we show that IL-9 transgenic mice (FVB/N-TG5), in comparison with FVB/NJ mice, display significantly enhanced eosinophilic airway inflammation, elevated serum total immunoglobulin E, and airway hyperresponsiveness following lung challenge with a natural antigen (Aspergillus fumigatus). These data support a central role for IL-9 in the complex pathogenesis of allergic inflammation.
人类特应性哮喘是一种复杂的遗传性气道炎症性疾病，与过敏性炎症和气道高反应性的临床体征相关。最近的研究表明，气道反应性的程度与小鼠肺中白细胞介素（IL）-9的表达密切相关。为了研究IL-9对气道高反应性的作用，并直接探讨其与气道炎症的关系，我们研究了过度表达IL-9的转基因小鼠。在本报告中，我们表明，与FVB/NJ小鼠相比，IL-9转基因小鼠（FVB/N-TG5）在用天然抗原（烟曲霉）攻击肺部后，表现出明显增强的嗜酸性气道炎症、血清总免疫球蛋白E升高和气道高反应性。这些数据支持IL-9在过敏性炎症复杂发病机制中起核心作用。
