Department of Dermatology, Taian Maternal and Child Health Care Hospital, Shandong, China.
Department of Pediatric Surgery, Taian City Central Hospital, Shandong, China.
J Biol Regul Homeost Agents. 2018 Mar-Apr;32(2):341-344.
Eczema, a common pediatric dermatosis with unclear pathogenesis, can seriously affect the life quality of children due to its recurrence and long course. Recent study has found that food specific IgG (sIgG) might be involved in the course of eczema. To analyze the correlation between childhood eczema and sIgG and evaluate the role of avoiding taking intolerance food in the treatment of childhood eczema, this study enrolled 216 children with eczema who were admitted to the Taian Maternal and Child Health Care Hospital, Shandong, China, between August 2014 and October 2015. They were divided into an eczema group (N = 140) and an allergy group (N = 76). Eighty healthy children who were admitted to the Department of Children Healthcare in the same period were selected as a control group. Enzymelinked immuno sorbent assay (ELISA) was used to detect the serum sIgG level. The result showed that the sIgG positive rates of children in the eczema group and allergy group were 91.4% and 93.4%, respectively, and the difference had no statistical significance (P > 0.05). However, the sIgG positive rates of children in the eczema group and allergy group were significantly higher than that in the control group (P less than 0.05). Milk and eggs were the major allergy-causing food for children with sIgG positive rates higher than 70%. The sIgG test results revealed that eggs had the highest allergenicity, followed by milk, tomatoes and soybeans, and pork was not highly sensitive. Therefore, it can be concluded that sIgG positive rate of children with eczema is high, and examination of food sIgG antibody in serum is valuable in the diagnosis and treatment of childhood eczema.
特应性皮炎是一种常见的儿科皮肤病，其发病机制尚不清楚，由于其反复发作和病程长，严重影响儿童的生活质量。最近的研究发现，食物特异性 IgG（sIgG）可能参与特应性皮炎的发病过程。为分析儿童特应性皮炎与 sIgG 的相关性，并评价回避不耐受食物在儿童特应性皮炎治疗中的作用，本研究选取 2014 年 8 月至 2015 年 10 月在山东省泰安市妇幼保健院就诊的 216 例特应性皮炎患儿为研究对象，分为特应性皮炎组（n=140）和过敏组（n=76）。另选取同期在儿童保健科就诊的 80 例健康儿童作为对照组。采用酶联免疫吸附试验（ELISA）检测血清 sIgG 水平。结果显示，特应性皮炎组和过敏组患儿 sIgG 阳性率分别为 91.4%、93.4%，差异无统计学意义（P＞0.05）；但均显著高于对照组（P＜0.05）。特应性皮炎组和过敏组患儿 sIgG 阳性的致敏食物主要为牛奶和鸡蛋，阳性率均＞70%。sIgG 检测结果显示，鸡蛋的致敏性最高，其次为牛奶、西红柿和大豆，猪肉不敏感。综上所述，特应性皮炎患儿 sIgG 阳性率较高，检测血清食物 sIgG 抗体对儿童特应性皮炎的诊断和治疗具有一定价值。
