Department of Internal Medicine/Geriatric and Palliative Medicine, McGovern Medical School, part of UTHealth, Houston, TX, USA.
Department of Orthopedic Surgery, McGovern Medical School, part of UTHealth, Houston, TX, USA.
J Clin Densitom. 2018 Jul-Sep;21(3):355-359. doi: 10.1016/j.jocd.2018.02.004. Epub 2018 Mar 27.
Altered bone quality due to the underlying metabolic changes of type 2 diabetes (T2D) has been hypothesized to affect bone strength, leading to increased fracture risk in patients with T2D. Lumbar spine trabecular bone score (LS-TBS), an indirect measure of trabecular microarchitecture, provides information on bone quality and has been associated with T2D. However, trabecular bone score (TBS) is also affected by demographic patterns and body size, and is expected to be different in people from various ethnic or racial backgrounds. Therefore, it is important to understand associations between T2D and TBS for each ethnic or racial group separately. Although the relationship between TBS and age has been reported to be similar between non-Hispanic Caucasians and Mexican Americans (MAs), data on associations of LS-TBS with T2D in older MAs are lacking. Here, we report associations between TBS and T2D in 149 older MA men and women. Participants are part of a cohort known as the Cameron County Hispanic Cohort in Texas who have high prevalence of obesity and poor glycemic control. Bone mineral density was not altered for MA women with T2D, but was significantly higher in MA men with T2D compared with MA men without diabetes. Low LS-TBS was associated with T2D in women in our study. Although low TBS was associated with older age in men, TBS did not show any significant association with T2D for men. These results are similar to those found in other studies of non-Hispanic whites with diabetes. LS-TBS may add value in diagnosing poor bone quality in older MA women with T2D regardless of bone mineral density scoring.
由于 2 型糖尿病（T2D）的潜在代谢变化，骨骼质量发生改变，据推测这会影响骨骼强度，导致 T2D 患者骨折风险增加。腰椎骨小梁骨评分（LS-TBS）是一种小梁微观结构的间接测量方法，提供了关于骨质量的信息，并且与 T2D 相关。然而，TBS 也受到人口统计学模式和体型的影响，并且预计在不同种族或种族背景的人群中会有所不同。因此，了解 T2D 与 TBS 之间的关联对于每个种族或种族群体都是很重要的。虽然 TBS 与年龄之间的关系在非西班牙裔白人和墨西哥裔美国人（MAs）之间的报道相似，但关于 LS-TBS 与老年 MAs 中 T2D 的关联的数据尚缺乏。在这里，我们报告了在 149 名老年 MA 男性和女性中 TBS 与 T2D 之间的关联。参与者是德克萨斯州卡梅伦县西班牙裔队列的一部分，该队列肥胖和血糖控制不良的患病率较高。患有 T2D 的 MA 女性的骨密度没有改变，但患有 T2D 的 MA 男性的骨密度明显高于没有糖尿病的 MA 男性。在我们的研究中，LS-TBS 与女性的 T2D 相关。尽管 TBS 与男性的年龄相关，但 TBS 与男性的 T2D 没有显著关联。这些结果与其他研究非西班牙裔白人与糖尿病的研究结果相似。LS-TBS 可能有助于诊断患有 T2D 的老年 MA 女性的骨质量较差，无论骨密度评分如何。
