Gabriel-Costa Daniele
Universidade da Força Aérea, Instituto de Ciências da Atividade Física, Programa de Pós-Graduação em Desempenho Humano Operacional, Rio de Janeiro, RJ, Brasil.
Pathophysiology. 2018 Dec;25(4):277-284. doi: 10.1016/j.pathophys.2018.04.003. Epub 2018 Apr 18.
Heart failure (HF) is a multifactorial disorder and is usually the end stage of many cardiovascular diseases (CVD). HF presents one of the highest morbidity and mortality indices worldwide and high costs to public health organizations. Myocardial infarction (MI) is the most prevalent CVD in the Western world and leads to HF when its management is inadequate. It has a destructive potential for heart cells and abruptly reduces the cardiac output, a clinical condition known as heart dysfunction that might progress to HF. Many acute and chronic adaptations occur due to MI that progress to HF, e.g., neurohumoral hyperactivity, inflammatory response and cardiac remodeling. Herein, we reviewed in simplistic manner the processes involved in setting of MI until the establishment of HF.
心力衰竭（HF）是一种多因素疾病，通常是许多心血管疾病（CVD）的终末期。HF是全球发病率和死亡率最高的疾病之一，给公共卫生组织带来高昂成本。心肌梗死（MI）是西方世界最常见的CVD，若治疗不当会导致HF。它对心脏细胞具有破坏潜力，并会突然降低心输出量，这种临床状况称为心脏功能障碍，可能会发展为HF。由于MI会进展为HF，会发生许多急性和慢性适应性变化，例如神经体液亢进、炎症反应和心脏重塑。在此，我们以简单的方式回顾了从MI发生到HF形成过程中涉及的各个环节。
