多西他赛联合顺铂治疗转移性外阴派杰病。

Docetaxel Combined With Cisplatin for Metastatic Extramammary Paget Disease.

机构信息

Department of Urology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.

Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.

出版信息

Clin Genitourin Cancer. 2018 Aug;16(4):e899-e901. doi: 10.1016/j.clgc.2018.03.004. Epub 2018 Mar 23.

DOI:10.1016/j.clgc.2018.03.004

PMID:29685612

Abstract

INTRODUCTION

Metastatic extramammary Paget disease (EMPD) as a rare intraepithelial carcinoma is fatal. However, no standardized chemotherapy has been established. We provided docetaxel combined with cisplatin to EMPD patients.

PATIENTS AND METHODS

A total of 8 patients with metastatic EMPD were included in this study between July 2010 and July 2015 (mean age, 64.4 years); they underwent a mean of 9.4 cycles of chemotherapy. All the patients were treated with chemotherapy (docetaxel 60 mg/m on day 1; cisplatin 25 mg/m on days 1-3) as first-line treatment for > 6 cycle (at least 21 days per cycle). Data on tumor response, time to progression, overall survival, and adverse events were collected.

RESULTS

After 2 cycles of chemotherapy, 4 patients experienced partial remission and 4 stable disease. The mean overall survival was 28.9 months, and the mean progression-free survival was 9.9 months.

CONCLUSION

Docetaxel combined with cisplatin might be a treatment option for metastatic EMPD, with high disease control rate and good overall survival.

摘要

简介

转移性乳房外 Paget 病（EMPD）作为一种罕见的上皮内癌是致命的。然而，尚未建立标准化的化疗方案。我们为 EMPD 患者提供了多西他赛联合顺铂治疗。

患者与方法

本研究共纳入 8 例 2010 年 7 月至 2015 年 7 月期间患有转移性 EMPD 的患者（平均年龄 64.4 岁）；他们平均接受了 9.4 个周期的化疗。所有患者均接受化疗（多西他赛 60 mg/m2，第 1 天；顺铂 25 mg/m2，第 1-3 天）作为一线治疗，至少 6 个周期（每个周期至少 21 天）。收集了肿瘤反应、疾病进展时间、总生存期和不良事件的数据。