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β-磷酸三钙和猪源性脱细胞骨细胞外基质在 3D 打印聚己内酯支架上协同作用促进骨再生。

Synergistic Effects of Beta Tri-Calcium Phosphate and Porcine-Derived Decellularized Bone Extracellular Matrix in 3D-Printed Polycaprolactone Scaffold on Bone Regeneration.

机构信息

Department of Orthopedic Surgery, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, Republic of Korea.

Research Institute, T&R Biofab Co., Ltd., 237 Sangidaehak-Ro, Siheung-si, Gyeonggi-do, 15073, Republic of Korea.

出版信息

Macromol Biosci. 2018 Jun;18(6):e1800025. doi: 10.1002/mabi.201800025. Epub 2018 Apr 24.

Abstract

Bone-derived extracellular matrix (ECM) is widely used in studies on bone regeneration because of its ability to provide a microenvironment of native bone tissue. However, a hydrogel, which is a main type of ECM application, is limited to use for bone graft substitutes due to relative lack of mechanical properties. The present study aims to fabricate a scaffold for guiding effective bone regeneration. A polycaprolactone (PCL)/beta-tricalcium phosphate (β-TCP)/bone decellularized extracellular matrix (dECM) scaffold capable of providing physical and physiological environment are fabricated using 3D printing technology and decoration method. PCL/β-TCP/bone dECM scaffolds exhibit excellent cell seeding efficiency, proliferation, and early and late osteogenic differentiation capacity in vitro. In addition, outstanding results of bone regeneration are observed in PCL/β-TCP/bone dECM scaffold group in the rabbit calvarial defect model in vivo. These results indicate that PCL/β-TCP/bone dECM scaffolds have an outstanding potential as bone graft substitutes for effective bone regeneration.

摘要

骨衍生细胞外基质 (ECM) 因其能够提供天然骨组织的微环境而被广泛用于骨再生研究。然而,由于相对缺乏机械性能,作为 ECM 主要应用类型之一的水凝胶仅限于用作骨移植物替代品。本研究旨在构建一种用于指导有效骨再生的支架。使用 3D 打印技术和修饰方法,制备了一种能够提供物理和生理环境的聚己内酯 (PCL)/β-磷酸三钙 (β-TCP)/骨脱细胞细胞外基质 (dECM) 支架。PCL/β-TCP/骨 dECM 支架在体外表现出优异的细胞接种效率、增殖能力以及早期和晚期成骨分化能力。此外,在体内兔颅骨缺损模型中,PCL/β-TCP/骨 dECM 支架组观察到出色的骨再生效果。这些结果表明,PCL/β-TCP/骨 dECM 支架具有作为有效骨再生的骨移植物替代品的巨大潜力。

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