Division of Neonatal Medicine, Department of Pediatrics, Children's Hospital of Richmond at VCU, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Division of Pulmonary Medicine, Department of Pediatrics, Children's Hospital of Richmond at VCU and School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Pediatr Pulmonol. 2018 Aug;53(8):1046-1052. doi: 10.1002/ppul.24022. Epub 2018 Apr 23.
Vascular endothelial growth factor (VEGF) and sphingolipid metabolites, sphingosine 1-phosphate (S1P), and ceramides are important to lung development and repair. We hypothesized specific sphingolipid and VEGF alterations would be associated with BPD development and aimed to investigate the early tracheal aspirate (TA) VEGF and S1P relationship with later diagnosis of preterm infant bronchopulmonary dysplasia, BPD.
TA VEGF and lipidomics were measured in TA from Infants <32 weeks gestational age at birth with and without later BPD. BPD was defined using the NICHD severity BPD definition. Clinical demographics and medical course were identified with statistical analysis performed with JMP, Statistical Analysis Software.
The analysis included 25 infants (9 NoBPD and 16 BPD) with mean gestational age of 27.8 ± 2.5 SD weeks and 25.1 ± 1.9 SD weeks respectively, P < 0.01. Later development of BPD was associated with elevated mean TA VEGF 604.3 ± 150.2 SE pg/mL versus NoBPD 120 ± 34.3 SE pg/mL, elevated S1P, 11.5 ± 2.3 SE pmol/mL versus NoBPD 4.8 ± 0.6 SE pmol/mL, and elevated selected ceramides during the first week of life.
Airway VEGF and sphingolipid metabolites were distinctly elevated within the first days of postnatal life in preterm infants with later BPD progression. These biomarkers may be useful as indicators of lung injury development or as targets to decrease BPD risk.
血管内皮生长因子（VEGF）和鞘脂代谢物，如鞘氨醇 1-磷酸（S1P）和神经酰胺，对于肺的发育和修复非常重要。我们假设特定的鞘脂和 VEGF 的改变与 BPD 的发生有关，并旨在研究早期气管抽吸物（TA）中的 VEGF 和 S1P 与早产儿支气管肺发育不良（BPD）的后期诊断之间的关系。
在出生时胎龄<32 周的有和无后期 BPD 的婴儿中，测量 TA 中的 VEGF 和脂质组学。BPD 采用 NICHD 严重 BPD 定义进行诊断。使用 JMP、统计分析软件进行临床人口统计学和医疗过程的统计分析。
该分析纳入了 25 名婴儿（9 名无 BPD 和 16 名 BPD），平均胎龄分别为 27.8±2.5 周和 25.1±1.9 周，P<0.01。后来发生 BPD 与 TA VEGF 平均值升高有关，604.3±150.2 SE pg/mL 比无 BPD 组的 120±34.3 SE pg/mL 高，S1P 升高，11.5±2.3 SE pmol/mL 比无 BPD 组的 4.8±0.6 SE pmol/mL 高，以及在生命的第一周内，选定的神经酰胺升高。
在患有后期 BPD 进展的早产儿中，在出生后的头几天内，气道中的 VEGF 和鞘脂代谢物明显升高。这些生物标志物可用作肺损伤发展的指标，或作为降低 BPD 风险的靶点。
